摘要
目的探讨依那普利叶酸片联用辛伐他片汀对H型高血压病患者血清炎症因子的影响。方法选取2017年4~8月间绵阳市第三人民医院收治的H型高血压患者100例作为研究对象,回顾性分析所有患者的临床资料,并按治疗方法分为观察组和对照组,每组各50例。观察组给予依那普利叶酸片+辛伐他汀片,对照组给予依那普利叶酸片。入院时收集患者性别、年龄、吸烟史、体重指数(BMI)、运动情况、血压、血清同型半胱氨酸(Hcy)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、高敏C反应蛋白(hs-CRP)资料。治疗4周后,复查患者血清TNF-α、IL-6、hsCRP、Hcy。结果治疗前,两组患者性别、年龄、吸烟史、BMI、血压、Hcy、TNF-α、IL-6、hs-CRP差异无统计学意义(P>0.05)。治疗后,观察组患者血清TNF-α、IL-6、hs-CRP水平明显低于对照组,差异具有统计学意义(P<0.05)。但是两组患者Hcy变化差异无统计学意义(P>0.05)。Pearson相关性分析结果显示,血清Hcy与TNF-α、IL-6、hsCRP之间均存在正相关性(r分别为0.708、0.682、0.674,P<0.01)。多元线性回归分析提示,年龄、BMI及收缩压升高是高同型半胱氨酸血症的危险因素。结论血清Hcy与血管炎性反应明显相关,且年龄、BMI及收缩压升高是高同型半胱氨酸血症的危险因素。依那普利叶酸片联用辛伐他汀片较单用依那普利叶酸片可更显著降低H型高血压患者TNF-α、IL-6、hs-CRP水平,降低血管炎性反应。
Objective To study the changes of serum inflammatory factors in patients with H-hypertension taking Enalapril maleate folic acid tablets combined with Simvastatin tablets. Methods 100 patients with H-hypertension who were admitted between April and August 2017 were selected in this study. Clinical data of all patients were analyzed retrospectively. They were divided into the observation group and the control group according to the random number table, 50 cases in each group. The observation group were given Enalapril folic acid tablets and Simvastatin tablets, while the control group were given Enalapril folic acid tablets. The gender, age, smoking history, body mass index（BMI）, exercise, blood pressure, serum homocysteine （Hcy）, tumor necrosis factor alpha （TNF-α）, interleukin 6 （IL-6）, high-sensitive C reactive protein （ hs-CRP） data were collected when admitted. All patients were required blood test for Hcy, TNF-α, IL-6 and hs-CRP after 4 weeks＇ treatment. Results There was no significant difference between the two groups in gender, age, smoking history, body mass index （BMI）, blood pressure, Hcy, TNF-α, IL-6, hs-CRP （ P 〉0.05）. The results showed that serum TNF-α, IL-6, hs-CRP levels of the observation group were significantly lower than those in the control group, the differences between the two groups were statistically significant （ P 〈0.05）. However, there was no significant difference in serum Hcy （ P 〉0.05）. Pearson correlation analysis showed that there was a positive correlation between serum Hcy and TNF-α, IL-6, hs-CRP （r was 0.708, 0.682, 0.674, respectively. P 〈0.01）. Multiple linear regression analysis indicated that age, BMI and systolic blood pressure were the risk factors of hyperhomocysteinemia. Conclusion Serum Hcy level is closely related to vascular inflammatory response, and age, BMI and systolic blood pressure increase are risk factors of hyperhomocysteinemia. Compared with taking Enalapril maleate folic acid tablets alone, taking Enalapril maleate folic acid tablets combined with Simvastatin tablets can significantly reduce the levels of serum TNF-α, IL-6 and hs-CRP, and reduce the inflammatory reaction in patients with H-hypertension.
作者
袁锐
张润峰
兰莉
YUAN Rui 1, ZHANG Run-feng 1, LAN Li 2.(1 The Clinical Medical School of Southwest Medical University, Luzhou Sichuan 646000, China; 2 Department of Cardiolagy ,The Third Hospital of Mianyang, Mianyang Sichuan 621000, China)
出处
《临床和实验医学杂志》
2018年第14期1532-1535,共4页
Journal of Clinical and Experimental Medicine
基金
绵阳市应用技术研究与开发项目(编号:15S-01-7)
