摘要
脂肪胰是近年被提出并研究,与肥胖、非酒精性脂肪性肝病、代谢综合征等多种疾病或病理状态相关的概念,特征为胰腺内脂肪沉积、胰腺实质脂肪变性,以及随之发生的胰腺代谢性异常.研究已证实脂肪胰与2型糖尿病、急性胰腺炎甚至胰腺肿瘤相关.可能是糖、脂代谢紊乱或者代谢综合征的一个早期标志物,还可能是胰腺相关疾病不良结局的预测因素.目前主要以影像学检查为主要诊断方法 .但因了解甚少,故而缺乏统一的命名、诊断标准、治疗共识或指南.本文总结了目前流行病学、病理生理、发病机制、诊断、治疗方面的研究现状,并提出需要进一步研究的方向.
Fatty pancreas is a newly proposed condition which is characterized by fat deposition and steatosis in the pancreas followed by outcome of pancreatic and metabolic complications. It has been found to be correlated with many metabolic disorders and a variety of diseases. Fatty pancreas has been associated with obesity, non-alcoholic fatty liver disease, metabolic syndrome, type 2 diabetes mellitus, acute and chronic pancreatitis, and even pancreatic carcinoma. Therefore, fatty pancreas might not only be an early marker of glucose or lipid metabolism disorders or metabolic syndrome, but also be a predictor of poor outcome of pancreatic related diseases. At present, imaging examination is the main diagnostic method. However, there is currently still a lack of a unified terminology, diagnostic criteria, treatment consensus, and guidelines due to very limited knowledge on this condition. Here we discuss the pathophysiology, pathogenesis, clinical implications, diagnosis, and treatment of fatty pancreas, with an aim to improve the early intervention, treatment, and prognosis prediction of fatty pancreas related metabolic disorders.
作者
牛春燕
吴方雄
Chun-Yan Niu;Fang-Xiong Wu(Department of Gastroenterology,Xiang’an Hospital of Xiamen University;Department of Gastroenterology,the First Affiliated Hospital of Xi’an Medical University Xi＇an 710077,Shaanxi Province,Chin)
出处
《世界华人消化杂志》
CAS
2018年第21期1280-1288,共9页
World Chinese Journal of Digestology
基金
陕西省重点研发计划,No.2017SF-274
陕西省教育厅科研计划,No.12JK0704~~
关键词
脂肪胰
肥胖
非酒精性脂肪性肝病
代谢综合征
研究现状
研究方向
Fatty pancreas
Obesity
Non-alcoholic fattyliver disease
Metabolic syndrome
Research status
Research direction
