摘要
目的探讨高同型半胱氨酸血症(HHcy)与颅内动脉狭窄支架置入术后再发症状性脑梗死的关系。方法选择120脑梗死患者,均行颅内动脉狭窄支架置入术,根据血浆同型半胱氨酸(Hcy)水平分为HHcy组62例(血Hcy≥15μmol/L)和非HHcy组58例(血Hcy<15μmol/L),并在术后给予抗血小板治疗。随访1.5年,比较2组脑梗死复发率和死亡率,分析影响脑梗死复发的危险因素。结果 HHcy组脑梗死复发率和死亡率均显著高于非HHcy组(P<0.05)。Logistic回归分析显示,脑梗死复发与HHcy有显著相关性(P<0.05,OR=1.112,95%CI为1.084~1.211)。结论高同型半胱氨酸血症可显著增加颅内动脉狭窄支架植入术后患者脑梗死再发的风险。
Objective To investigate the relationship between hyperhomocysteinemia（ HHcy） and recurrent symptomatic cerebral infarction after stent implantation for intracranial arterial stenosis. Methods A total of 120 patients with cerebral infarction were treated with stent implantation for intracranial arterial stenosis. According to plasma homocysteine（ Hcy） level,the patients were divided into HHcy group（ n = 62,blood Hcy≥15 μmol/L） and non-HHcy group（ n = 58,blood Hcy 15 μmol/L）,and all the patients were given anti-platelet therapy after surgery. After 1. 5 years of follow-up,the recurrence rate and mortality of cerebral infarction were compared between two groups,and the risk factors affecting the recurrence of cerebral infarction were analyzed. Results The recurrence rate and mortality of HHcy group were significantly higher than those of non-HHcy group（ P〈0. 05）. Logistic regression analysis showed that the recurrence of cerebral infarction was significantly related to HHcy（ P〈0. 05,OR = 1. 112,95% CI： 1. 084 - 1. 211）. Conclusion Hyperhomocysteinemia can significantly increase the risk of recurrent cerebral infarction after stent implantation for intracranial arterial stenosis.
作者
汪洋
吴磊
尹博文
庞燕
WANG Yang;WU Lei;YIN Bowen;PANG Yan(Department of Neurology;Department of Neurosurgery,The First Hospital of Qinhuangdao,Qinhuangdao,Hebei,066000)
出处
《实用临床医药杂志》
CAS
2018年第17期15-17,共3页
Journal of Clinical Medicine in Practice
基金
河北省秦皇岛市科学技术局项目(201602A136)
关键词
脑梗死
复发
高同型半胱氨酸血症
死亡率
颅内动脉狭窄
支架
cerebral infarction
recurrence
hyperhomocysteinemia
mortality
intracrani-al arterial stenosis
stent
