摘要
目的观察银杏叶提取物对短暂性脑缺血发作患者血液流变学及神经功能的影响。方法选取2015年6月至2017年4月于某院接受治疗的94例短暂性脑缺血发作患者,依据随机数字表法将其分为对照组与观察组,每组47例。对照组接受尼莫地平治疗,观察组接受银杏叶提取物联合尼莫地平治疗。对比两组疗效、血液流变学指标水平、神经功能及不良反应情况。结果观察组治疗总有效率(93.62%)高于对照组(74.47%),差异具有统计学意义(P<0.05);治疗后,观察组血浆黏度(1.83±0.09)m Pa·s、纤维蛋白原(3.27±0.81)g/L、血小板聚集率(43.84±2.17)%等指标水平均低于对照组的(2.32±0.12)mPa·s、(4.02±0.83)g/L、(58.16±2.21)%,且NIHSS评分(10.63±4.42)分低于对照组的(15.12±9.31)分,差异具有统计学意义(P<0.05);两组治疗期间均无明显不良反应出现。结论银杏叶提取物治疗短暂性脑缺血发作疗效较佳,可改善患者血液流变学指标,促进神经功能恢复,且用药安全性高。
Objective To observe the effect of ginkgo biloba extract on hemorheology and nerve function in patients with transient ischemic attack（TIA）.Me thods 94 TIA patients treated in a hospital from June 2015 to April2017 were selected and divided into the control group and the observation group by random number table,with 47 cases in each group.The control group were given nimodipine while the observation group were treated with ginkgo biloba extract combined with nimodipine.The efficacy,hemorheology indexes,nerve function and adverse reactions were compared between the two groups.Re s ults The total effective rate of the observation group（93.62%） was higher than that（74.47%） of the control group and the difference showed statistical significance（ P 0.05）.After treatment,the plasma viscosity,fibrinogen,platelet aggregation rate in the observation group [（1.83 ±0.09）m Pa·s,（3.27±0.81）g/L,（43.84±2.17）%] were lower than those in the control group[（2.32±0.12）mPa·s,（4.02±0.83）g/L,（58.16±2.21）% ].The NIHSS score of the observation group（10.63 ±4.42） was lower than that of the control group（15.12 ±9.31） and the difference showed statistical significance（ P 0.05）.There were no obvious adverse reactions in two groups during treatment.Conclus ion Ginkgo biloba extract was effective and safe in the treatment of TIA,improving hemorheology indexes and promoting the recovery of nerve function.
出处
《中国疗养医学》
2018年第8期790-792,共3页
Chinese Journal of Convalescent Medicine
