摘要
目的研究氯吡格雷抵抗细胞色素P4502C19（CYP2C19）基因多态性与复发性缺血性脑卒中的相关性。方法选取2015年4月至2017年3月天津市南开医院收治的38例复发性缺血性脑卒中患者，按照使用氯吡格雷后是否有抵抗将患者分为抵抗组（13例）和非抵抗组（25例）。分析2个单核苷酸多态性（SNPs）的等位基因频率和基因型频率，检测两组2个SNPs的分布情况。结果CYP2C19（636G〉A，rs4986893）和CYP2C19（681G〉A，rs4244285）等位基因和基因频率符合Hardy—Weinberg平衡（P〉0．05）。非抵抗组CYP2C19＊2（rs4244285）GG型分布率显著高于抵抗组（68．00％比30．77％，P〈0．05），GA＋AA型分布率显著低于抵抗组（32．00％比69．23％，P〈0．05），两组CYP2C19＊3（rs4986893）GG型（76．00％比92．31％）、AG＋AA型（24．00％比7．69％）分布率比较差异均无统计学意义（均P〉0．05）。结论氯吡格雷抵抗CYP2C19基因多态性和复发性缺血性脑卒中密切相关。
Objective To study the relationship between clopidogrel resistance to cytochrome P4502C19 （CYP2C19） gene polymorphism and recurrent ischemic stroke. Methods A total of 38 patients with recurrent isehemic stroke admitted to Tianjin Nankai Hospital from April 2015 to March 2017 were enrolled, and they were divided into a resistance group （13 cases） and a non-resistance group （25 cases） according to elopidogrel resistance being present or not. The allele frequencies and genotype frequencies of two single nucleotide polymorphisms （SNPs） were analyzed, and the distributions of two SNPs in the two groups were analyzed. Results The CYP2C19 （636G〉A, rs4986893） and CYP2C19 （681G〉A, rs4244285） alleles and gene frequencies were consistent with Hardy-Weinberg balance （P 〉 0.05）, The GG pattern distribution rate of CYP2C19＊2 （rs4244285） in the non-resistance group was significantly higher than that in the resistance group （68.00% vs. 30.77%, P 〈 0.05）, and the GA＋AA type distribution rate in the non-resistance group was significantly lower than that in the resistance group （32.00% vs. 69.23%, P 〈 0.05）, the comparisons of distribution rates of CYP2C19＂3 （rs4986893） GG type （76.00% vs. 92.31%）, AG＋AA type （24.00% ± 7.69%） between two groups had no statistical significant differences （P 〉 0.05）. Conclusion The clopidogrel resistance to CYP2C19 gene polymorphism is closely related to recurrent ischemie stroke.
作者
李彦弢
王珩
刘琳
Li Yantao;Wang Heng;Liu Lin(Department of Treatment of the Pro-Disease,Tianjin Nankai Hospital,Tianjin 300100,China)
出处
《中国中西医结合急救杂志》
CAS
CSCD
北大核心
2018年第4期396-398,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
天津市医药卫生中医中西医结合科研课题（2015028）
