摘要
目的探讨复方石韦胶囊联合加替沙星片治疗尿路感染的临床疗效。方法选取2016年3月—2017年12月西安交通大学第一附属医院收治的尿路感染患者146例为研究对象,对照组口服加替沙星片,0.4 g/次,1次/d。治疗组在对照组治疗的基础上口服复方石韦胶囊,2.0 g/次,3次/d。两组患者均连用14 d。观察两组的临床疗效,比较两组的临床症状消退时间、退热时间、尿检白细胞转阴时间和细菌培养转阴情况。结果治疗后,对照组和治疗组的总有效率分别为89.04%、95.89%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组临床症状消退时间、退热时间、尿检白细胞转阴时间均短于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,对照组和治疗组的尿细菌培养转阴率分别为84.93%、97.26%,两组比较差异有统计学意义(P<0.05)。结论复方石韦胶囊联合加替沙星片治疗尿路感染具有较好的临床疗效,缩短临床症状消退时间、退热时间、尿检白细胞转阴时间,提高尿细菌培养转阴率,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Compound Shiwei Capsules combined with Gatifloxacin Tablets in treatment of urinary tract infection. Methods Patients（146 cases） with urinary tract infection in urinary tract infection from March 2016 to December 2017 were randomly divided into control and treatment groups, and each group had 73 cases. Patients in the control group were po administered with Gatifloxacin Tablets, 0.4 g/time, once daily. Patients in the treatment group were po administered with Compound Shiwei Capsules on the basis of the control group, 2.0 g/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and clinical symptoms subsided time, antipyretic time, urine leukocyte negative time, and bacterial culture negative situation in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 89.04% and 95.89%, respectively, and there was difference between two groups（P〈 0.05）. After treatment, clinical symptoms subsided time, antipyretic time, and urine leukocyte negative time in the treatment group were shorter than those in the control group, and there was difference between two groups（P〈 0.05）. After treatment, the negative rate of urine bacteria culture in the control and treatment groups were 84.93% and 97.26%, respectively, and there was difference between two groups（P〈 0.05）. Conclusion Compound Shiwei Capsules combined with Gatifloxacin Tablets has clinical curative effect in treatment of urinary tract infection, can shorten clinical symptoms subsided time, antipyretic time, and urine leukocyte negative time, can increase the negative rate of urine bacteria culture, which has a certain clinical application value.
作者
孙青
罗俊
赵亮
付琦芳
张蕾
李维凤
SUN Qing;LUO Jun;ZHAO Liang;FU Qi-fang;ZHANG Lei;LI Wei-feng(Department of Pharmacy,the First Affiliated Hospital of Xi＇an Jiaotong University,Xi＇an 710061,China;Retirement Family,the First Affiliated Hospital of Xi＇an Jiaotong University,Xi＇an 710061,China;Medical Records Room,the First Affiliated Hospital of Xi＇an Jiaotong University,Xi＇an 710061,China;Department of Clinical Pharmacy,Red Cross Hospital Affiliated to Xi＇an Jiaotong University,Xi＇an 710054,China;Department of Hepatobiliary Surgery,the First Affiliated Hospital of Xi＇an Jiaotong University,Xi＇an 710061,China;Colleges of PharmaCy,Xi＇an Jiaotong University,Xi＇an 710061,China)
出处
《现代药物与临床》
CAS
2018年第8期2099-2102,共4页
Drugs & Clinic
关键词
复方石韦胶囊
加替沙星片
尿路感染
临床症状消退时间
退热时间
尿检白细胞转阴时间
细菌培养转阴
Compound Shiwei Capsules
Gatifloxacin Tablets
urinary tract infection
clinical symptoms subsided time
antipyretictime
urine leukocyte negative time
bacterial culture negative situation
