摘要
目的探讨依达拉奉联合丁苯酞对急性脑梗死患者血清氨基末端脑钠肽前体(NT-proBNP)、C反应蛋白(CRP)水平变化及预后的影响。方法选择商丘市中心医院96例急性脑梗死患者,建档顺序分为治疗组和对照组各48例。2组均予以常规治疗,于此基础上对照组仅采取依达拉奉治疗,观察组联合丁苯酞治疗,均持续治疗2周。统计对比2组治疗前、治疗2周后神经功能缺损评分(NIHSS)、日常生活能力评分(BI),检测2组治疗前、治疗2周后血清NT-proBNP、CRP水平,观察2组临床疗效和不良反应发生情况。结果 2组治疗前NIHSS评分、BI评分及血清NT-proBNP、CRP水平比较,差异均无统计学意义(P>0.05);治疗2周后观察组BI评分较对照组升高,NIHSS评分及血清NT-proBNP、CRP水平较对照组下降,差异均有统计学意义(P<0.05);观察组总有效率为89.58%(43/48)高于对照组70.83%(34/48),差异有统计学意义(P<0.05);观察组不良反应发生率6.25%(3/48)与对照组4.17%(2/48)相比,差异无统计学意义(P>0.05)。结论急性脑梗死患者联合应用依达拉奉与丁苯酞治疗效果显著,可有效降低患者血清氨基末端脑钠肽前体、C反应蛋白水平,提高其日常生活能力,且安全性较高。
Objective To investigate the effect of edaravone combined with butylphthalide on N terminalpro brain natriuretic peptide （NT proBNP）,C reactive protein （CRP） and prognosis of patients with acute cerebral infarction. Methods 96 patients with acute cerebral infarction in our hospital were selected and divided into groups according to the archiving order,48 cases in each group.The two groups were given conventional treatment.On this basis,the control group was treated with edaravone,while the observation group was treated with butylphthalide based on the control group.Both groups were treated for 2 weeks.The neurological deficit scores （NIHSS） and activities of daily living （BI） were compared between the two groups before treatment and 2 weeks after treatment.The serum levels of NT proBNP and CRP were detected in two groups before treatment and 2 weeks after treatment.The clinical efficacy and adverse reactions of the two groups were observed. Results There was insignificant difference in the NIHSS score,BI score and serum levels of NT proBNP and CRP between the two groups before treatment（ P 〉0.05）.After treatment for 2 weeks,the BI score of the observation group was higher than that of the control group,while the NIHSS score and serum levels of NT proBNP and CRP were lower than those of the control group,and the differences were statistically significant（ P 〈0.05）.After treatment,the total effective rate of the observation group was 89.58% （43/48）,higher than that of the control group 70.83% （34/48）,and the difference was statistically significant（ P 〈0.05）.The incidence of adverse reactions in the observation group was 6.25% （3/48）,which was not significantly different from that in the control group[4.17% （2/48）]（ P 〉0.05）. Conclusion The treatment effect of edaravone combined with butylphthalide in the treatment of patients with acute cerebral infarction is significant.It can effectively reduce the serum levels of N terminalpro brain natriuretic peptide and C reactive protein,and improve their activity of daily livin.Besides,it has higher safety.
作者
蒋玉侠
JIANG Yuxia(Department of Neurology,Shangqiu Central Hospital,Shangqiu 476000,CHina)
出处
《中国实用神经疾病杂志》
2018年第17期1899-1904,共6页
Chinese Journal of Practical Nervous Diseases
关键词
急性脑梗死
依达拉奉
丁苯酞
氨基末端脑钠肽前体
C反应蛋白
神经功能
日常生活能力
Acute cerebral infarction；Edaravone；Butylphthalide；N terminalpro brain natriuretic peptide；C reactive protein；Nerve function；Activity of daily living
