摘要
近年来,我国脂肪肝的发病率逐年上升,非酒精性脂肪肝(NAFLD)是其中的一种类型,研究发现NAFLD与炎症状态以及肾功能减退等密切相关。本文通过分析NAFLD患者(观察组)和健康人群(对照组)乳酸脱氢酶值(LDH)、估计肾小球滤过率(e GFR)的差异,旨在研究影响NAFLD的危险因素及这些因素的性别差异。结果发现NAFLD患者中男性LDH值、e GFR值均低于女性,差异具有统计学意义(P<0.05)。说明LDH浓度过高和肾功能减退都与NAFLD有关联,且女性NAFLD患者LDH浓度更高、而男性患者的肾功能减退更严重。因此及时关注LDH浓度和肾功能可指导NAFLD患者临床诊疗。
At present, the incidence of fatty liver is increasing year by year in our country. Non-alcoholic fatty liver disease （NAFLD） is one of the types. This project analyzed the differences in LDH and eGFR between NAFLD patients（observation group） and healthy individuals（control group ）, and the aim was to study the risk factors of NAFLD and the gender differences in these factors. The results showed that the male LDH and eGFR of the observation group were lower than that of the female, and the difference was statistically significant （ P 〈0.05）. It is indicated that rising LDH and decreased renal function are associated with NAFLD, and the concentration of LDH in female NAFLD patients is higher and the renal function damage of male is more serious than that of female. Therefore, timely attention to LDH concentration and renal function in patients with NAFLD can guide clinical diagnosis and treatment.
作者
张海玉
刘自华
ZHANG Haiyu;LIU Zihua(Laboratory of Hanzhoung People s Hospital,Hanzhong 723000,Shannxi,China)
出处
《中南医学科学杂志》
CAS
2018年第5期538-539,554,共3页
Medical Science Journal of Central South China
关键词
非酒精性脂肪肝
乳酸脱氢酶值
肾小球滤过率值
性别差异
Non-alcoholic fatty liver disease
lactate dehydrogenase value
glomerular filtration rate
gender difference
