摘要
心肌纤维化是由多种因素导致的心肌细胞及其间质的改变,是多种心血管疾病发展到一定严重程度时的共同病理表现。对于肥大细胞致器官纤维化的研究主要集中于肝、肾、肺、小肠、皮肤等器官,近年来发现其也参与心肌的纤维化。研究表明肥大细胞具有促进心肌纤维化的作用,其脱颗粒物质影响心肌纤维化的发生与发展。中药领域在防治心肌纤维化方面具有显著疗效,已成为近年来研究的热点。本文就肥大细胞在心肌纤维化中的作用机制及中药领域防治心肌纤维化的研究进展进行综述。
Myocardial fibrosis is a variety of cardiomyocytes and its interstitial changes caused by a variety of factors.It is a common pathological manifestation of many kinds of cardiovascular diseases to a certain extent.The study of mast cell fibrosis is mainly concentrated in the liver,kidney,lung,small intestine,skin and other organs.In recent years,it has also been found to be involved in the process of myocardial fibrosis.Studies have shown that mast cells play a role in promoting myocardial fibrosis,and their degranulation substances affect the occurrence and development of myocardial fibrosis.Traditional Chinese medicine has a significant effect in the prevention and treatment of myocardial fibrosis,and has become a hot topic in recent years.In this review,we reviewed the mechanism of mast cells in myocardial fibrosis and the progress in the prevention and treatment of myocardial fibrosis in Chinese medicine.
作者
王丹妮
傅水莲
倪赛宏
何丽明
洪铁
WANG Dan-nil;FU Shui-lian;NI Sai-hong;HE Li-Ming;HONG Tie(Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China;College of Chinese Medicine Materials,Jilin Agricultural University,Changchun130118,China)
出处
《人参研究》
2018年第4期47-51,共5页
Ginseng Research
