摘要
目的探讨CD64检测在类风湿关节炎(RA)合并感染中的临床意义。方法根据2010年美国风湿病学会和欧洲抗风湿病联盟修订的RA分类标准和评分体系,选取2016年9月至2017年6月来该院就诊的RA患者64例,根据病原学结果分为RA合并感染组29例,RA活动期组35例。纳入同期健康体检者30例为对照组。测定各组中性粒细胞CD64与C反应蛋白(CRP)、红细胞沉降率(ESR)、降钙素原(PCT)水平,分析其相关性,绘制受试者工作曲线(ROC曲线)。结果 RA合并感染组CD64为4.08(3.24~6.29),明显高于RA活动期组及对照组,差异有统计学意义(P<0.05)。RA合并感染组CD64水平与PCT呈正相关(r=0.409,P<0.05),RA活动期组CD64水平与CRP、ESR、PCT无相关性(P>0.05)。ROC曲线分析显示,CD64诊断RA合并感染的灵敏度为82.8%,特异度为97.1%。结论中性粒细胞CD64在区分RA合并感染及RA病情活动中具有较高的灵敏度及特异度,可为早期诊断及治疗提供帮助。
Objective To investigate the clinical significance of CD64 detection in rheumatoid arthritis （RA） complicating infection. Methods According to the RA classification criteria and scoring system revised by the American Rheumatism Association and European League against Rheumatism,64 patients with RA in this hospital from September 2016 to June 2017 were selected and divided into the RA complicating infection group （29 cases） and active stage group （35 cases）.Contemporaneous 30 persons undergoing healthy physical examination were included as the control group.The levels of neutrophil CD64,CRP,ESR and PCT were detected and their correlation was analyzed.The receiver operating characteristic（ROC） curve was drawn. Results The CD64 level in the RA complicating infection group was 4.08（3.24-6.29）,which was significantly higher than that in the RA active stage group and control group,the difference was statistically significant （ P 〈 0.05）.The CD64 level in the RA complicating infection group was positively correlated with PCT （ r = 0.409 , P 〈0.05）;while the CD64 level in the RA active stage group had no correlation with CRP,ESR and PCT （ P 〉0.05）.The ROC curve analysis showed that the sensitivity of CD64 for diagnosing RA complicating infection was 82.8% and the specificity was 97.1%. Conclusion Neutrophil CD64 level has higher sensitivity and specificity in discrimination between RA complicating infection and active RA,and provides help for early diagnosis and treatment.
作者
刘洋
曹玲
张朝霞
LIU Yang;CAO Ling;ZHANG Zhaoxia(Department of Clinical Laboratory,First Affiliated Hospital of Xinjiang MedicalUniversity,Urumqi,Xinjiang 830054,China)
出处
《检验医学与临床》
CAS
2018年第19期2872-2875,共4页
Laboratory Medicine and Clinic
