摘要
目的评价认知行为疗法与利培酮对强迫症的增效作用。方法将符合DSM-Ⅴ强迫症诊断标准,使用足量舍曲林12周,Y-BOCS>16分的50例强迫症患者随机分为研究组和对照组,每组各25例。2组在继续使用舍曲林的基础上,研究组给予每周1次,为期12周的认知行为治疗;对照组给予12周的利培酮治疗(2.28±0.56)mg。使用Y-BOCS量表、临床疗效总评量表评定临床疗效和不良反应。结果认知行为治疗组患者总有效率为76.0%,利培酮组患者总有效率48.0%,两组疗效比较有统计学差异(P<0.01);研究组强迫症状总分、强迫思维因子分、强迫行为因子分较对照组显著降低(P<0.01),研究组临床疗效总评量表病情严重程度(SI)、疗效总评(GI)评分明显低于对照组(P<0.01),疗效指数(EI)评分明显高于对照组(P<0.01)。结论认知行为疗法对强迫症的增效作用优于利培酮,且安全性高。
Objective To assess the efficacy of Cognitive-Behavioral Therapy（ CBT） vs Risperidone for Augmenting effect in obsessive-compulsive disorder. Methods Fifty OCD patients（ based on DSM-V criteria） who were treated sufficient sertraline for 12 weeks,and remained at least moderately symptomatic（ Y-BOCS score 16） were randomly divided into the study group（ 25） and control group（ 25）. Each group was treated with sertraline. Study group received 12 sessions CBT over 12 weeks. Control group received Risperidone at the same time（ 2.28 ± 0. 56） mg. Clinical assessments were conducted by Yale-Brown obsessive compulsive scale（ Y-BOCS）,Clinical Global Impression（ CGI） before and after treatment. Results At the end of treatment there was significant different in the total effective rate between study group and control group（ 76. 0% vs 48%,χ~2= 4. 16,P〈0. 01）. The scores of the total,obsessional thoughts and compulsive behavior of Y-BOCS as well as SI,GI of CGI were lower significantly in study group than control group（ P〈0. 01）. EI of CGI was higher significantly in study group than control group（ P〈0. 01）. Conclusion Cognitive behavioral therapy is more effective than risperidone in the treatment of obsessive-compulsive disorder.
作者
王学永
王云鹏
王菁
张立平
赵约翰
WANG Xueyong;WANG Yunpeng;WANG Jing;ZHANG Liping;ZHAO Yuehan(Department of Psychiatry,Weifang People＇s Hospital,Weifang 261041,China;Department of Psychiatry,Weifang People＇s Hospital of Hi-tech Zone;Department of Psychiatry,Weifang People＇s Hospital)
出处
《潍坊医学院学报》
2018年第4期271-273,共3页
Acta Academiae Medicinae Weifang
基金
潍坊市科学技术发展项目(项目编号:2016YX098)
关键词
强迫症
认知行为疗法
利培酮
增效作用
Obsessive-compulsive disorder
Cognitive-Behavioral Therapy
Risperidone
Augmenting effect
