摘要
恶性肿瘤严重危害人类健康,其发生发展有白细胞介素等众多细胞因子的参与。IL-35是IL-12家族的新成员,近年来研究发现,IL-35作为免疫抑制因子可调节肿瘤微环境促进多种肿瘤的发生发展并与疾病预后密切相关,而仍有小部分研究显示出其抑癌作用。因此,本文将回顾IL-35在肿瘤中的最新研究进展。
Malignant tumors are a serious threat to human health, and many cytokines such as interleukin involve in its occurrence and development. IL-35 is a new member of IL-12 family. Recent studies showed that IL- 35 as a immunosuppressive factor can regulate the tumor microenvironment and promote the occurrence and development of various tumors and is closely related to the prognosis of the disease. However, a small number of studies suggested its tumor suppressor effect. Therefore, we will review the latest research progress of IL-35 in tumors.
作者
韩丽
李培武
伏旭
HAN Li;LI Peiwu;FU Xu(Emergency Research Institution of Lanzhou University Second Hospital,Lanzhou 730030,China)
出处
《免疫学杂志》
CAS
CSCD
北大核心
2018年第10期906-910,916,共6页
Immunological Journal
基金
兰州大学第二医院博士生/硕士生导师科研基金(sd-kyjj-07)
