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外用肺表面活性物质治疗胎粪吸入综合征的临床应用研究

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摘要 目的研究外用肺泡表面活性物质(PS)治疗胎粪吸入综合征的临床应用。方法选取我院收治的84例胎粪吸入综合征(MAS)患儿为研究对象,随机分为观察组和对照组,每组各42例。对照组予以基础治疗,观察组在对照组的基础上予以PS治疗。比较两组治疗前及治疗后24h的患儿氧合指数(OI)、动脉/肺泡分压比值(a/APO_2),PaO_2、PaCO_2等动脉血气指标,机械通气时间、住院时间及住院费用等临床指标以及气胸、呼吸机相关肺炎、急性肺损伤等并发症发生情况。结果治疗后,观察组OI指数显著低于对照组(P<0.05),a/APO_2值显著高于对照组(P<0.05);观察组PaO_2水平高于对照组,PaCO_2水平低于对照组,比较差异具有统计学意义(P<0.05);观察组的机械通气时间与住院时间均短于对照组,比较差异具有统计学意义(P<0.05);在住院费用方面,两组比较差异无统计学意义(P>0.05);观察组的并发症发生率为14.29%,低于对照组的35.71%,两组比较差异具有统计学意义(P<0.05)。结论应用PS治疗胎粪吸入综合征能够明显改善肺氧合功能、动脉血气指标,还可缩短机械通气时间与住院时间,降低并发症的发生率,改善患儿预后,增加满意度,具有一定的临床意义。
出处 《福建医药杂志》 CAS 2018年第5期114-116,共3页 Fujian Medical Journal
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