摘要
目的研究不同剂量的重组人干扰素α-2b雾化吸入对毛细支气管炎治疗效果的差异。方法选择景德镇市妇幼保健院2016年12月至2018年6月收治的60例毛细支气管炎患儿,其中男性40例,女20例,年龄1.5~11.0个月。随机分为高剂量组和低剂量组,各30例。高剂量组男性20例,女性10例;年龄2.5~11.0个月,平均年龄5.35个月;体质量6~9 kg,平均体质量7.75 kg;发病时间为1~6 d,平均发病时间3.18 d。低剂量组男性20例,女性10例;年龄1.5~11.0个月,平均年龄5.31个月;体质量6~11 kg,平均体质量7.57 kg;发病时间为1~6 d,平均发病时间3.25 d。在常规治疗的基础上采用不同剂量的重组人干扰素α-2b雾化吸入治疗,从患儿咳嗽喘息改善时间、肺部体征消失时间等方面进行数据的收集整理与对比分析。结果两组患儿在男女比例、发病年龄、体质量、发病时间各因素差异均无统计学意义(P>0.05)。高剂量组总有效率是83.3%,低剂量组总有效率是53.3%;差异有统计学意义(χ~2=6.241,P=0.044<0.05)。高剂量组与低剂量组喘息消失时间(4.02 d±2.53 d vs 5.08 d±2.26 d)、喘鸣音消失时间(4.22 d±2.63 d vs 5.28 d±2.46 d)比较,差异有统计学意义(P<0.05);高剂量组咳嗽消失时间(6.17±1.94)d,低剂量组(6.10±3.33)d,差异无统计学意义(P>0.05)。两组均未见明显不良反应。结论高剂量组的重组人干扰α-2b雾化吸入治疗毛细支气管炎的有效率高于低剂量组,但咳嗽消失时间两者差异无统计学意义。
Objective To study the therapeutic effect of different doses of recombinant human interferon alpha-2 b inhalation in bronchiolitis. Methods From December 2016 to June 2018, a total of 60 children with bronchiolitis were enrolled, which included 40 males and 20 females with aged 1.5-11.0 months. All of them were randomly divided into high-dose group（n = 30,20 males and 10 females; aged 2.5-11.0 months with mean age of 5.35 months; body weight was 6-9 kg with mean body weight of 7.75 kg; onset time was 1-6 days with mean onset time of 3.18 days） and low-dose group（n = 30, 20 males and 10 females; aged 1.5-11.0 months with mean age of 5.31 months; body weight was 6-11 kg with mean body weight of 7.57 kg;onset time was 1-6 days with mean onset time of 3.25 days）. On the basis of routine treatment, which treated with different doses of recombinant human interferon alpha 2 b atomization inhalation, and the data were collected and analyzed in improve-ment time of cough and time for the disappearance of lung signs. Results There was no significant difference in ratio of gender, age of onset, body weight and time of onset between 2 groups（P〉0.05）. The total effective rate in high-dose group was83.3 %, and in low-dose group was 53.3 %, which showed statistically significant（ χ-2= 6.241, P = 0.044 〈0.05）. The differences of asthmatic disappearance time in high-dose group（4.02 days ± 2.53 days） and low-dose group（5.08 days ± 2.26 days）and wheezing, disappearance time（4.22 days ± 2.63 days vs 5.28 days ± 2.46 days） were statistically significant（P〉0.05）; There was no statistically significant difference in cough disappearance time between high-dose group[（6.17 ± 1.94） days] and lowdose group[（6.10 ± 3.33） days]（P〈0.05）. There was no obvious adverse reaction in 2 groups. Conclusion It is demonstrated that the effective rate of high-dose of recombinant human interference alpha-2 b atomization inhalation on bronchiolitis is higher than that of low-dose, but there is no significant difference in coughing disappearance time.
作者
冯博
黄杨
FENG Bo;HUANG Yang(Department of Pediatrics;Department of Pharmacy,Maternal and Child Health Hospital of Jingdezhen,Jingdezhen 333000,Jiangxi,China)
出处
《生物医学工程与临床》
CAS
2018年第5期561-564,共4页
Biomedical Engineering and Clinical Medicine
