摘要
目的探究消化内镜治疗非静脉曲张性上消化道出血的临床疗效及对患者血清IL-8、TNF-a的影响。方法将68例非静脉曲张性上消化道出血患者分为两组,其中对照组采用常规内科治疗,观察组在对照组基础上采用消化内镜止血治疗。治疗后对比两组止血效果、血清IL-8、TNF-α水平。结果观察组治疗总有效率显著高于对照组,具有统计学差异(P <0. 05);观察组肠鸣音恢复时间为(2. 01±0. 34) d,出血停止时间为(1. 93±0. 48) d及住院时间为(7. 89±2. 81) d显著短于对照组,且再出血率低于对照组,具有统计学差异(P <0. 05);两组IL-8、TNF-α水平经治疗后均显著低于治疗前,且观察组IL-8水平为(642. 3±76. 8) pg/m L,TNF-α水平为(50. 9±7. 8) pg/m L均显著低于对照组,具有统计学差异(P <0. 05)。结论非静脉曲张性上消化道出血患者在常规内科治疗基础上经消化内镜止血治疗可有效促进患者恢复,控制再出血,减少机体炎症反应,疗效确切,值得临床推广采用。
Objective To explore the clinical efficacy of digestive endoscopy in the treatment of non variceal upper gastrointestinal bleeding and its effect on serum IL - 8 and TNF - a. Methods 68 cases of non variceal upper gastrointesti- nal bleeding were divided into two groups. The control group was treated with routine medical treatment, and the observation group was treated with digestive endoscopy on the basis of the control group. After treatment, hemostatic effect, serum IL - 8 and TNF - alpha levels were compared between the two groups. Results The total effective rate of treatment in the obser- vation group was significantly higher than that of the control group, There was significant difference （ P 〈 0.05 ） ; The recover y time of the observation group was （2.01± 0.34） d, the time of bleeding stopped （ 1.93 ± 0.48 ） d and the time of hospital- ization was （7.89 ± 2.81 ） d significantly shorter than the control group, and the rebleeding rate was significantly lower than that of the control group, There was significant difference （ P 〈 0.05 ） ; Two groups of IL - 8. The level of TNF - alpha was significantly lower than that before treatment, and the level of IL -8 in the observation group was （642.3 ± 76.8 ） pg/ml, and the level of TNF -α （50.9 ± 7.8 ） pg/ml was significantly lower than that of the control group. There was significant difference （P 〈 0.05 ）. Conclusion The patients with non variceal upper gastrointestinal bleeding can effectively promote the recovery, control rebleeding and reduce the inflammatory reaction of the body-. It is worthy of clinical application.
作者
文政伟
李秋兰
何均辉
WEN Zhengwei;LI Qiulan;HE Junhui(The People＇s Hospital of Songgang,Shenzhen 518000,China)
出处
《现代医院》
2018年第9期1340-1342,共3页
Modern Hospitals
关键词
消化内镜
非静脉曲张性上消化道出血
再出血
炎症反应
Digestive Endoscopy
Non Variceal Upper Gastrointestinal Bleeding
Rebleeding
hfflannnatory Re-sponse
