摘要
目的探讨血清脑钠肽(BNP)在急性肺栓塞(APE)近期预后评价中的价值。方法选择APE并行外周血BNP检查的84例患者,按照BNP水平,分为BNP升高组41例与BNP正常组43例。比较两组患者住院期间不良事件发生率(肺动脉高压、右心功能不全、心源性休克、死亡)。通过ROC曲线分析BNP对APE不良预后的诊断价值及确定最佳临界值。结果两组肺动脉高压及右心功能不全发生率经统计学处理差异有统计学意义。两组心源性休克发生率及死亡率经统计学处理差异无统计学意义。BNP诊断APE不良预后的ROC曲线下面积为0.829,最佳临界值为93.15 pg/m L(敏感度:69.0%,特异度:92.3%)。结论 APE患者BNP升高时,近期预后不佳。BNP对APE不良预后有很好的诊断价值。
Objective to explore value of serum brain natriuretic peptide（BNP） in short-term prognosis of acute pulmonary embolism（APE）. Methods choose 84 cases APE patients with peripheral blood BNP examination, according to BNP level, divide them into BNP elevation group（41 cases） and BNP normal group（43 cases）. Compare adverse events incidence（pulmonary hypertension, right heart insufficiency, cardiogenic shock, and death） of two groups during hospitalization. Analyze diagnostic value of BNP for APE poor prognosis and determine the best critical value with ROC curve. Results incidence difference of pulmonary hypertension and right ventricular dysfunction was statistically significant between two groups. Cardiogenic shock incidence and mortality showed no significant difference between two groups. Area under ROC curve of BNP diagnosed APE poor prognosis was 0.829, the best critical value was 93.15 pg/m L（sensitivity： 69%, specificity： 92.3%）. Conclusion short-term prognosis is no good when increasing BNP of APE patients, and BNP has good diagnostic value for APE poor prognosis.
作者
张艳敏
付萌
庞桂芬
ZHANG Yan-min;FU Meng;PANG Gui-fen(Chengde Medical College Affiliated Hospital,Chengde,Hebei,06700)
出处
《智慧健康》
2018年第21期125-126,共2页
Smart Healthcare
关键词
肺栓塞
脑钠肽
预后
Pulmonary embolism
Brain natriuretic peptide
Prognosis
