摘要
目的探讨重症哮喘实施急诊抢救联合小剂量肾上腺素治疗的临床效果。方法随机选取辽宁省锦州市紧急救援中心于2016年5月至2017年5月收治的72例重症哮喘患者作为研究对象,采用随机数字表法将其分为对照组和观察组,各36例。对照组患者实施急诊抢救治疗,观察组患者实施急诊抢救联合小剂量肾上腺素治疗,分析两组患者的治疗总有效率、生命体征指标、临床症状评分、不良事件发生率。结果治疗总有效率比较显示,观察组(94.4%)高于对照组(77.8%)(χ2=4.181,P<0.05);心率、收缩压、舒张压、呼吸频率、动脉血氧饱和度(Sa O2)比较显示观察组(91.4±24.6)次/min、(130.2±26.5)mm Hg、(84.7±16.8)mm Hg、(89.6±5.4)次/min、(898.8±5.4)%优于对照组(122.1±27.4)次/min、(144.2±28.4)mm Hg、(93.7±18.9)mm Hg、(105.3±5.6)次/min、(105.3±5.6)%(P<0.05,t值依次为5.002、2.163、2.135、12.109、4.936);临床症状评分观察组低于对照组(P<0.05);不良事件发生率比较显示,观察组(2.8%)低于对照组(16.7%)(χ2=3.956,P<0.05)。结论急诊抢救联合小剂量肾上腺素治疗重症哮喘效果显著,既可改善患者临床症状,还可提高患者生命体征、减少不良反应发生率。
Objective To evaluate the clinical effect of emergency treatment of severe asthma combined with small dose adrenaline.Methods A total of 72 patients with severe asthma admitted to Jinzhou emergency rescue center, Liaoning from May 2016 to May 2017 were randomly selected. They were divided into control group （n=36） and observation group （n=36） by random number table. The control group received emergency rescue treatment, and the observation group received emergency rescue combined with low-dose adrenaline treatment. The total effective rate, vital signs,clinical symptom score and incidence of adverse events in the two groups were analyzed.Results The total treatment efficacy comparison showed that 94.4% of the observation group was higher than the control group （77.8%） （x^2=4.181,P〈0.05）; the heart rate,systolic blood pressure, diastolic pressure, respiratory rate, SaO2 comparison showed that the observation group （91.4±24.6） times/min, （130.2±26.5） mmHg, （84.7±16.8） mmHg, （89.6±5.4） times/min, （898.8±5.4）% better than the control group （122.1±27.4）/min, （144.2±28.4） mmHg, （93.7± 18.9） mmHg,（105.3±5.6） beats/min, （105.3±5.6）% （P〈0.05, t values were 5.002, 2.163, 2.135, 12.109, 4.936, respectively）; the clinical symptom scores in the observation group were lower than the control Group （P〈0.05）; Comparison of incidence of adverse events showed 2.8% in the observation group was lower than the control group 16.7% （x^2=3.956,P〈0.05）.Conclusion Emergency treatment of severe asthma combined with small dose of epinephrine is effective,it can not only improve the clinical symptoms of patients, but also improve the vital signs and reduce the incidence of adverse reactions.
出处
《中国药物经济学》
2018年第7期52-54,共3页
China Journal of Pharmaceutical Economics
关键词
重症哮喘
急诊抢救
小剂量肾上腺素
Severe asthma
Emergency treatment
Small dose adrenaline
