摘要
目的探索P300在评估脑震荡后综合征(postconcussion syndrome,PCS)患者严重程度中的应用价值。方法挑选符合《ICD-10精神与行为障碍分类》中PCS诊断标准的患者19名,性别、年龄、文化程度匹配的健康对照18名。采用视觉Oddball范式对上述被试进行P300检测;同时使用日常生活能力量表(activity of daily living scale,ADL)、社会功能缺陷筛选量表(social disability screening schedule,SDSS)等量表进行评估。结果PCS组ADL评分及SDSS评分显著高于健康对照组(P<0.001)。PCS组Fz、Cz、CPz及Pz点的波幅显著低于健康对照组(P<0.05)。PCS组Fz、Cz、CPz及Pz点的波幅与ADL评分呈负相关(P<0.05)。以ADL评分、SDSS评分、Fz、Cz、CPz及Pz点的潜伏期和波幅为协变量,可以得到拟合较好的判断被试是否患有PCS的方程。结论P300的波幅可以反映PCS的严重程度,即P300波幅越低,PCS患者的病情更为严重;通过ADL评分、SDSS评分和P300波幅及潜伏期拟合得到的方程可能可以作为初步判断是否患有PCS的客观指标。
Objective To explore the value of applying P300 to evaluation of the severity of postconcussion syndrome （PCS）. Methods According to the ICD-10 criteria, 19 patients with PCS were enrolled in the present study and 18 healthy volunteers whose age, gender and educational level matched with the patients were enrolled as the control group. All subjects were examined by P300 according to oddball paradigm and evaluated by activity of daily living scale （ADL） and social disability screening schedule （SDSS）. Results The scores of ADL and SDSS were significantly higher in patients than healthy controls （P〈0.001）. The amplitudes of Fz, Cz, CPz and Pz was significantly lower in patients than those in healthy controls （P〈0.05）. In patients group, the amplitudes ofFz, Cz, CPz and Pz was negatively correlated with the scores of ADL and SDSS （P〈0.05）. A well fitted equation for diagnosis of PCS can be obtained by treating the scores of ADL and SDSS, the latency and amplitude of Fz, Cz, CPz and Pz as concomitant variables.Conclusion The amplitude of P300 can reflect the severity of PCS, which means the lower the amplitude of P300 indicates the more severity of PCS. The fitted equation that was set by the scores of ADL and SDSS , the latency and amplitude of Fz、 Cz, CPz and Pz may be a preliminary objective indicator for the diagnosis of PCS.
作者
李豪喆
刘露
张盛宇
陈琛
刘超
樊慧雨
邢燕
蔡伟雄
张钦廷
Li Haozhe;Liu Lu;Zhang Shengyu;Chen Chen;Liu Chao;Fan Huiyu;Xing Yan;Cai Weixiong;Zhang Qinting(Shanghai Key Laboratory of Forensic Medicine,Shanghai Forensic Service Platform,Academy of Forensic Science,Shanghai 200063,China;Zhejiang Provincial Hospital of Traditional Chinese Medicine,Hangzhou 310000,China)
出处
《中国法医学杂志》
CSCD
2018年第5期453-457,共5页
Chinese Journal of Forensic Medicine
基金
"十三五"国家重点研发计划项目(2016YFC0800701)
国家自然科学基金(81801881
81001354)
中央级科研院所科研专项(GY2018G-7
GY2018G-8)
国家社会科学基金项目(13BFX054)
上海市法医学重点实验室资助项目(17DZ2273200)
上海市司法鉴定专业技术服务平台资助项目(16DZ2290900)
