摘要
目的探讨清开灵注射液静脉滴注联合羟苄唑滴眼液滴眼治疗儿童单纯疱疹病毒性角膜炎的临床疗效。方法选取2016年9月至2018年1月收治的单纯疱疹病毒性角膜炎患儿84例为研究对象,随机分为治疗组与对照组,每组42例。对照组患儿仅给予羟苄唑滴眼液滴眼治疗,治疗组患儿给予清开灵注射液静脉滴注联合羟苄唑滴眼液滴眼治疗。两组均以10 d为1个疗程,连续治疗3个疗程。对比两组临床疗效、角膜损伤愈合时间、疼痛缓解时间、治疗前后T淋巴细胞亚群水平、视力改善情况,并观察两组不良反应发生情况。结果治疗组与对照组患儿总有效率分别95. 24%、73. 81%,两组比较有统计学差异(P <0. 01);治疗组患儿角膜损伤愈合时间[(7. 18±0. 45) d vs(10. 43±0. 57) d]、疼痛缓解时间[(2. 09±0. 26) d vs (5. 45±0. 61) d]均显著短于对照组(P均<0. 05);治疗后,两组患儿CD4+/CD8+、CD4+均较治疗前明显升高,CD8+较治疗前降低(P均<0. 05),且治疗组患儿的CD4+/CD8+、CD4+高于对照组,CD8+低于对照组(P均<0. 05);治疗后,两组患儿的总体视力较治疗前明显改善,且治疗组视力改善情况优于对照组(P均<0. 05)。结论清开灵注射液静脉滴注联合羟苄唑滴眼液局部治疗儿童单纯疱疹病毒性角膜炎,临床疗效显著,且能有效改善患儿免疫功能及视力。
Objective To investigate the clinical effect of Qingkailing injection combined with hydrobenzole eye drops in the treatment of children with herpes simplex virus（HSV） keratitis. Methods Eighty-four children with HSV keratitis treated from September 2016 to January 2018 were selected as the objects and randomly divided into treatment group and control group（n = 42,each）. Hydrobenzole eye drops alone was given in control group,and Qingkailing injection combined with hydrobenzole eye drops was given in treatment group. The clinical efficacy,corneal injury healing time,pain relief time,T lymphocyte subsets levels before and after treatment and visual acuity were compared between two groups,and adverse reactions were observed also. Results The total effective rate in treatment group was significantly higher than that in control group（95. 24% vs 73. 81%,P〈0.01）. Compared with control group,the corneal injury healing time[（7. 18 ±0. 45） d vs（10. 43 ± 0. 57） d] and the pain relief time[（2. 09 ± 0. 26） d vs（5. 45 ± 0. 61） d] significantly shortened in treatment group（all P〈0.05）. After treatment in both groups,the levels of CD4＋/CD8＋and CD4＋were significantly higher than those before treatment,and CD8＋level was lower than that before treatment（all P〈0.05）; and compared with control group,the levels of CD4＋/CD8＋and CD4＋increased,and CD8＋level decreased significantly in treatment group（all P〈0.05）. After treatment,the visual acuity of the children in both groups improved significantly,and it in treatment group was better than that in control group（all P〈0.05）. Conclusions Qingkailing injection combined with hydrobenzole eye drop is effective in the treatment of children with HSV keratitis and can effectively improve the immune function and visual acuity of children.
作者
郭宝
张德勇
蔡文茜
孙莉
GUO Bao;ZHANG De-yong;CAI Wen-qian;SUN Li(Department of Pediatric Ophthalmology,Xuzhou Children＇s Hospital,Xuzhou,Jiangsu 221006,China)
出处
《中国临床研究》
CAS
2018年第10期1413-1415,共3页
Chinese Journal of Clinical Research
