摘要
自闭症是一种神经系统发育障碍疾病,患者常缺乏社会功能,并伴有语言和非语言交流障碍以及行为刻板和乐趣局限等特点。肠道菌群是指人肠道中庞大的微生物群落,不仅影响消化吸收能力和抵御各种感染,同时通过脑-肠轴影响着肠道神经系统、神经内分泌系统和免疫等系统间接地调控大脑功能,进而与某些疾病相关联。本文从自闭症的病因、肠道菌群的功能及肠道菌群与自闭症潜在的发病机制三方面的研究进展进行综述,以阐明自闭症发病的另一个危险因素,旨在对自闭症的早期诊断、及时干预及新的治疗思路提供帮助。
Autism spectrum disorder（ASD）,a kind of neurodevelopmental disorder,is often associated the lack of social functions,and accompanied by language and nonverbal communication abnormalities,as well as by stereotyped behavior and interest limitation.Gut microbiota,a large microbial community in human intestinal tract,can not only affect digestion and absorption capacity and fight infections,but also influence intestinal nervous system,neuroendocrine system and immune system and regulate cerebral function through brain-gut-axis.Therefore,gut microbiota is associated with some diseases.In this paper,we summarize the causes of ASD,functions of gut microbiota and underlying pathogenesis of ASD to elucidate another risk factor for ASD.This review will be helpful to ASD patients in early diagnosis,timely intervention and new ideas of treatment.
作者
刘文凤
王荣斌
LIU Wen-feng;WANG Rong-bin(The First Clinical Medical College of Nanchang University,Nanchang 330006,China)
出处
《实用临床医学（江西）》
CAS
2018年第9期104-107,共4页
Practical Clinical Medicine
关键词
肠道菌群
自闭症
病因学
发病机制
综述
gut microbiota
autism spectrum disorder
etiology
pathogenesis
review
