摘要
胰腺癌肝转移的预后极差,手术切除机会少,传统放化疗对其疗效也不理想。免疫治疗作为新的肿瘤治疗策略,能够通过增强患者免疫功能以对抗肿瘤,有望成为胰腺癌肝转移的有效治疗方案。针对免疫调节剂、单克隆抗体、免疫检查点抑制剂、过继细胞免疫和肿瘤疫苗方面,总结了近年来免疫疗法在胰腺癌肝转移治疗中的研究进展,认为联合治疗方案具有积极的应用前景。
Patients with liver metastasis of pancreatic cancer have poor prognosis and few opportunities for surgery,and conventional radiochemotherapy lacks a satisfactory effect. As a new therapeutic strategy for tumor,immunotherapy fights against cancer by enhancing patients′immune function and may thus become an effective treatment regimen for liver metastasis of pancreatic cancer. This article reviews the latestresearch advances in immunotherapy for liver metastasis of pancreatic cancer from the aspects of immunomodulator,monoclonal antibody,immune checkpoint inhibitor,adoptive cellular immunotherapy,and tumor vaccine and points out that a combined treatment regimen has apromising future in clinical application.
作者
金添强
徐锋
戴朝六
JIN Tianqiang;XU Feng;DAI Chaoliu(Department of Hepatobiliary and Splenic Surgery,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2018年第11期2469-2474,共6页
Journal of Clinical Hepatology
基金
沈阳市科学技术计划项目(17-230-9-16)
关键词
胰腺肿瘤
肝肿瘤
肿瘤转移
免疫疗法
综述
pancreatic neoplasms
liver neoplasms
neoplasm metastasis
immunotherapy
review
