摘要
目的分析羟考酮缓释片所致不良反应的发生特点及规律,为临床合理使用提供参考。方法回顾性分析医院2017年1月至12月羟考酮缓释片不良反应发生情况,对80例发生不良反应的患者资料(包括性别、年龄、使用剂量、累及器官/系统、不良反应程度、不良反应预后及处理等)进行统计和分析。结果 80例不良反应患者中,男54例,女26例; 60岁以上患者53例(66. 25%);羟考酮日剂量20 mg 32例(40. 00%);累及器官/系统主要为胃肠道系统损害68例(85. 00%),中枢及外周神经系统损害7例(8. 75%); 2例严重不良反应分别表现为呼吸衰竭、谵妄。结论医务人员应掌握羟考酮缓释片发生不良反应的规律及特点,加强合理用药管理及临床用药监护,以保障临床用药的安全性及有效性。
Objective To analyze the characteristics and regularity of adverse drug reactions（ADRs） induced by Oxycodone Prolonged- Release Tablets, so as to provide reference for rational drug use in clinical practice. Methods The ADRs induced by Oxycodone Pro- longed- Release Tablets in our hospital from January to December in 2017 were retrospectively analyzed. Totally 80 patients with ADRs were counted and analyzed from gender, age, dosage, organs/systems involvement, severity of ADRs, prognosis and treatment of ADRs. Results Among 80 patients with ADRs, 54 patients were males, 26 patients were females and 53 patients were over 60 years old（66.25% ）. ADRs mainly occurred when the administration dosage was 20 mg per day（32 cases, 40. 00% ）. Organs/systems involved in ADR were mainly lesion of gastrointestinal system（68 cases, 85.00% ）, followed by central and peripheral nervous system damage（7 cases, 8.75% ）, the symptoms of 2 serious ADRs were respiratory depression and delirium. Conclusion Medical staff should master the regularity and characteristics of ADRs induced by Oxycodone Prolonged- Release Tablets, while strengthen rational drug use management and monitoring to ensure the safety and effectiveness of clinical drug use.
作者
马维娜
王纯
闵新
严俊
Ma Weina;Wang Chun;Min Xin;Yan Jun(Jiading District Central Hospital Affiliated to Shanghai University of Medicine and Health Sciences,Shanghai,China 201800)
出处
《中国药业》
CAS
2018年第23期74-76,共3页
China Pharmaceuticals
基金
上海健康医学院种子基金项目[HMSF-17-12-010]
关键词
羟考酮缓释片
药品不良反应
合理用药
Oxycodone Prolonged- Release Tablets
adverse drug reaction
rational drug use
