摘要
目的探讨肿瘤异常蛋白(TAP)在肺癌组织中的表达情况及其与患者临床特征的关系和临床意义。方法选取125例初治肺癌患者作为肺癌组,选取同期体检的120例健康者作为健康对照组。检测两组研究对象外周血中TAP的相对表达水平,并评价其在肺癌中的临床价值。结果肺癌组患者肺癌组织中TAP的阳性表达率为66.4%(83/125),明显高于健康对照组健康者正常组织中的15.0%(18/120),差异有统计学意义(P<0.01)。Ⅲ+Ⅳ肺癌组织中的TAP的阳性表达率明显高于Ⅰ+Ⅱ期肺癌组织中的TAP的阳性表达率,差异有统计学意义(P<0.01);不同性别、年龄、组织学分型肺癌患者的肺癌组织中TAP的阳性表达率比较,差异均无统计学意义(P>0.05)。结论 TAP检测可以作为肺癌诊断的辅助方法,可与其他指标共同对肺癌进行筛查。
Objective To investigate the expression of tumor abnormal protein （TAP） in lung cancer, its relationship with clinical characteristics of patients and its clinical significance.Method One hundred and twenty-five patients firstly diagnosed as lung cancer were recruited as lung cancer group, and 120 healthy subjects undertaking physical examination in the out-patient department were collected as healthy control group. The expression of TAP in peripheral blood was examined, and the clinical value in lung cancer was evaluated.Result The positive expression rate of TAP in lung cancer patients （66.4%, 83/125） was significantly higher than that in healthy subjects （15.0%, 18/120）, and the differences were statistically significant （P〈0.01）. The positive expression rate of TAP in patients of stage III＋IV lung cancer was significantly higher than that in patients of stage I＋II, and the differences were statistically significant （P〈0.01）. There was no significant difference in the positive expression rate of TAP among patients with different sex, age and histological classi- fication （P〉0.05）. Conclusion TAP can be used as an auxiliary method for the diagnosis of lung cancer, and can be a screen marker for lung cancer combined with other indicators.
作者
徐瑞彤
徐艳玲
王彤
成红艳
戴冠群
XU Ruitong;XU Yanling;WANG Tong;CHENG Hongyan;DAI Guanqun(Department of General Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu,China)
出处
《癌症进展》
2018年第13期1644-1646,共3页
Oncology Progress
关键词
肿瘤异常蛋白
肿瘤标志物
肺癌
诊断
tumor abnormal protein
tumor marker
lung cancer
diagnosis
