摘要
目的 通过对矿物中药硇砂成份分析和有效提取 ,制备出A、N和Z剂进行动物肝癌治疗研究。方法 体外以人 772 1肝癌细胞系进行不同药物成份及浓度杀癌细胞效果评价 ;体内用裸小鼠 772 1肝癌模型肿瘤内注射治疗效果观察。结果 体外与抗癌药物表阿霉素、无水乙醇及冰醋酸等比较 ,所筛选有效成分均优于或相当于对照 ,且与药物浓度相关。体内实验可使肿瘤体积显著缩小 ,直至瘤块坏死吸收消失。结论 抗肿瘤药硇砂有效成分提取剂在肝癌动物模型治疗上 ,效果优于无水乙醇 ,是肝癌局部治疗一种可供选择方法。
Objective By means of component analysis and valid extraction of Chinese traditional anti\|tumor mineral drug Sal\|Ammoniae, we prepared A?N and Z agents to offer a remedy to liver cancer by intra\|tumor injection . Methods In vitro we adopted L7721 liver cancer cells strains to conduct the cancer cell killing effect evaluation; In vivo naked rice loaded with L7721 cancer strain were used to appraise the anticancer effect by means of intra\|tumor injection.Results In vitro experiment showed our agents have the same or even better anticancer effect comparing with pharmorubicin or absolute alcohol ,also having significant dosage\|effect correlative relationships; In vivo all agents notably decreased the volume of the tumor, even led to completely necrosis and vanish of the mass. Conclusion To be an anti\|tumor drug sal\|Ammoniae active constituent extraction liquid have obviously cure effect on liver cancer of the model animals, even superior to absolute alcohol that were widely used in clinical practice.
出处
《肿瘤防治研究》
CAS
CSCD
2002年第5期365-366,372,共3页
Cancer Research on Prevention and Treatment
基金
天津市科委重点项目<肝癌综合治疗研究>子课题 (0 0 3112 311)
