摘要
目的:探讨术前中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)对上皮性卵巢癌患者预后的评估价值。方法:收集2005年11月至2012年12月在天津市中心妇产科医院初治且经手术治疗的153例卵巢良性肿瘤和206例上皮性卵巢癌患者的临床病理资料,比较术前NLR和PLR在卵巢良恶性肿瘤的区别,根据统计学方法选取NLR和PLR临界值,分析NLR和PLR与上皮性卵巢癌临床病理因素的关系。通过单因素及多因素分析评估术前NLR和PLR对患者术后生存的影响。结果:术前NLR和PLR水平在上皮性卵巢癌中明显高于卵巢良性肿瘤。选取NLR=2.62和PLR=173分别作为临界值。单因素分析结果显示,FIGO分期晚、中-低分化、腹水、脉管癌栓、CA125≥35、NLR≥2.62、PLR≥173是影响患者术后无病生存期(DFS)的危险因素(P<0.05);FIGO分期晚、腹水、脉管癌栓、CA125≥35、PLR≥173是影响患者术后总生存期(OS)的危险因素(P<0.05)。多因素分析显示,FIGO分期晚、NLR≥2.62、脉管癌栓是上皮性卵巢癌患者DFS的独立危险因素(P<0.05)。结论:NLR和PLR方便测得且价格便宜,对卵巢癌的预后有一定的评估价值。
Objective: To evaluate the prognostic value of pretreatment serum NLR and PLR in epithelial ovarian cancer. Methods: The complete clinical and pathological information of 206 patients with epithlial ovarian cancer at the time of surgery and 153 ovarian begine tumors were selected to the Tianjin Central Hospital of Obetetrics and Gynecology during a period from Nov. 2005 to Dec. 2012. Comparing preoperative NLR and PLR in the difference between benign and malignant ovarian tumors,according to the statistical methods to select NLR and PLR critical value,Analysis relationship between NLR and PLR and clinical pathological factors in epithelial ovarian cancer,and preoperative serum NLR and PLR effect on postoperative survival was assessed by univariate and multivariate analysis. Result: Preoperative serum NLR and PLR levels were significantly higher in epithelial ovarian cancer than in benign ovarian tumors. NLR = 2. 62 and PLR = 173 were selected as the cut-off value. The univariate analysis showed that advanced FIGO stage,differentiation of moderate to poorly,ascites,lymphovascular space invasion( LVSI),CA125≥35、NLR≥2. 62 and PLR≥173 were risk factors for diseasefree survival( DFS),while advanced FIGO stage,ascites,LVSI,CA125 ≥35 and PLR ≥173were all risk factors for overall survival( OS). Cox's multivariate analysis showed that advanced FIGO stage,LVSI and preoperative NLR≥2. 62 were epithelial ovarian cancer patients with independent risk factors for DFS. Conclusions: NLR and PLR are inexpensive and easy tests to perform,which showed potentially predictive value in epithelial ovarian cancer.
出处
《现代妇产科进展》
CSCD
北大核心
2016年第6期433-436,共4页
Progress in Obstetrics and Gynecology
