摘要
目的探讨老年急性髓系白血病(acute myeloid leukemia,AML)患者CD56表达水平及预后意义。方法回顾性分析江苏省人民医院血液科118例初诊≥60岁AML患者CD56的表达情况,比较CD56阳性(n=24例)和CD56阴性(n=94例)患者的临床特征、治疗效果及生存时间。结果除细胞遗传学因素外,CD56阳性和CD56阴性患者在年龄、性别、FAB分型、初诊时白细胞计数、血红蛋白、血小板计数及骨髓原始细胞计数方面均无统计学意义(P>0.05);CD56阳性与CD56阴性患者诱导1个疗程后CR率(58.3%54.3%,P=0.720)和OR率(75%vs 64.9%,P=0.348)没有明显差异,但CD56阴性患者的中位OS明显长于CD56阳性患者(18个月vs9个月,P=0.026)。多因素Cox回归提示年龄≥70岁、首次诱导后CR及CD56阳性是老年AML患者的独立预后因素。结论 CD56可能是老年初诊AML预后不良的标记之一。
Objective To explore the expression and prognostic significance of CD56in elderly patients with acute myeloid leukemia(AML).Methods A retrospective analysis was made to the expression of CD56in118patients≥60years old newly diagnosed to be with AML,and the clinical features,curative effect and overall survival(OS)of24patients in positive CD56group and94patients in negative CD56group were compared.Results There existed no statistical difference in age,sex,FAB classification,white blood cell count,hemoglobin,platelet count and bone marrow count between the2groups(P>0.05);the complete remission(CR)rates and the overall survival(OS)rates of the patients in the2groups after1course of induction were of no statistical difference[(58.3%vs54.3%,P=0.720),(75%vs64.9%,P=0.348)]while the medium OS rate of the patients in negative CD56group was much longer than that of the patients in positive CD56group(18months vs9months,P=0.026);Multivariate Cox analysis indicated that age≥70years old,CR rate and positive CD56after the initial induction were the independent prognostic factors.Conclusions CD56may be one of the markers of poor prognosis in the elderly with newly diagnosed AML.
作者
赵慧慧
黄佳瑜
朱雨
洪鸣
赵晓丽
朱晗
连芸
吴汉新
陆化
李建勇
钱思轩
Zhao Huihui;Huang Jiayu;Zhu Yu;Hong Ming;Zhao Xiaoli;Zhu Han;Lian Yun;Wu Hanxin;Lu Hua;Li Jianyong;Qian Sixuan(Department of Hematology, the Second Affiliated Hospital to Southeast University, Nanjing, 210003,P. R. China;Department of Hematology,the First Affiliated Hospital to Nanjing Medical University/Jiangsu Provincial People's Hospital, Nanjing, 210029,P. R. China)
出处
《老年医学与保健》
CAS
2017年第6期492-495,共4页
Geriatrics & Health Care
基金
国家自然科学基金(81570134
81270614
81570141)
