摘要
白细胞介素-34(IL-34)是近年来新发现的白细胞介素家族成员,其受体有巨噬细胞集落刺激因子-1受体(CSF-1R)和蛋白酪氨酸磷酸酶ζ受体(RPTP-ζ)。目前,已知IL-34与集落刺激因子-1(CSF-1)的生物学活性相似但不完全相同,在各种炎症和自身免疫性疾病中发挥重要作用。此外,发现IL-34在急性白血病、骨巨细胞瘤、肝癌等多种肿瘤的发病中起到一定作用。因此,研究IL-34与肿瘤的关系有助于了解肿瘤的发病机制,并为肿瘤的治疗提供新的方向。
IL-34is a recently discovered member of interleukin family,and its receptors include macrophage colony stimulating factor-1receptor(CSF-1R)and receptor like protein tyrosine phosphatase zeta(RPTP-ζ).So far,it is known that IL-34and CSF-1have similar biological activities but not identical,and they play an important role in a variety of inflammatory and autoimmune diseases.In addition,it may play a role in the pathogenesis of tumor diseases,such as osteoclastoma,acute leukemia,hepatocellular carcinoma.Therefore,the studies of the relation between tumor and IL-34contribute to understanding the pathogenesis of tumor,and they provide a new direction for the treatment of tumor.
作者
李静
胡艳
王丽红
徐前飞
刘亚蒙
葛健
LI Jing;HU Yan;WANG Lihong;XU Qianfei;LIU Yameng;GE Jian(Department of Hemopathology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui230022,China)
出处
《安徽医药》
CAS
2017年第12期2139-2141,共3页
Anhui Medical and Pharmaceutical Journal
基金
国家自然科学基金(81200371)
安徽省自然科学基金(1208085QH154
1708085MH224)
高等学校博士学科点专项科研基金联合资助课题(20123420120011)
安徽省教育厅高校优秀拔尖人才培养资助项目(gxyq ZD2017029)
