摘要
龋病作为一种感染性疾病,口腔微生物群落在其发生发展过程中的具体作用机制尚无定论。高通量测序技术及宏组学技术的应用为龋病病因研究和龋病的微生态防治提供了新的思路。本文从与龋病相关口腔微生物群落的基因组学、宏基因组学、宏转录组学、宏蛋白质组学及宏代谢组学等方面的研究进展进行综述。
The pathogenic mechanisms by which oral microbial communities affect the occurrence and development of dental caries remain unclear.Applications that make use of high-through put sequencing technologies and metaomics approaches to research dental caries etiology can provide new ideas about disease prevention and treatment.In this article,we review advanced research presented in metaomics studies,including genomic,metagenomic,metatranscriptomic,metaproteomic and metabolomics studies of dental caries.
作者
霍媛媛(综述)
韩轩(综述)
李雨庆(综述)
邹静(审校)
HUO Yuanyuan;HAN Xuan;HAN Xuan;ZOU Jing(State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)
出处
《口腔疾病防治》
2018年第3期195-199,共5页
Journal of Prevention and Treatment for Stomatological Diseases
基金
国家自然科学基金(81470035)
