摘要
目的监测宝安区育龄妇女孕前甲状腺激素水平并对甲状腺疾病患者进行孕前早期干预,为临床相关疾病的治疗提供借鉴和参考。方法以宝安区下辖新安、西乡、福永、石岩、松岗、沙井6个街道2016年1月~2017年1月参加免费孕前优生健康检查的育龄妇女8000例为研究对象。随访统计患者妊娠率、早孕流产率、妊娠并发症发生率、胎儿畸形发生率、新生儿甲状腺疾病发生率及产后抑郁症的发病率。结果甲状腺功能异常(TSH<0.34μmoL/L或TSH>5.60μmoL/L)有172例,其中28例甲状腺功能亢进(均TSH=0.31moL/L),发病率为0.35%;144例甲状腺功能低下(均TSH=5.73moL/L),发病率为1.8%。所有甲状腺功能异常妇女中61例接受干预治疗护理,111例未接受治疗护理。对比接受干预和拒绝接受干预妇女情况发现,两组患者年龄情况、TSH水平基本相当,但未接受干预患者中甲减患者占多数(P<0.05)。在妊娠率、流产率、胎儿畸形发生率、新生儿甲状腺疾病发生率及产后抑郁症的发病率等方面,甲状腺功能正常的妇女均显著较优,差异有统计学意义(P<0.01)。治疗患者的妊娠率、新生儿甲状腺疾病发生情况与拒绝干预患者相比,差异有统计学意义(P<0.01)。结论对于育龄妇女孕前甲状腺激素水平检测及对甲状腺疾病患者进行孕前早期干预具有十分重要的意义,值得临床借鉴和参考。
Objective To monitor the pre-pregnancy thyroid hormone level of women of childbearing age in Baoan area and to intervene early pregnancy in patients with thyroid diseases,which provides reference and reference for the treatment of clinically relevant diseases.Methods8000women of childbearing age who participated in the free pre-pregnancy health examination were studied by the baoan district under the jurisdiction of xinan,xixiang,fuyong,shiyan,songgang and shajing6streets.The pregnancy rate,the incidence of early pregnancy,the incidence of pregnancy complications,the incidence of fetal malformation,the incidence of neonatal thyroid diseases and the incidence of postpartum depression were statistically analyzed.Results There were172cases of thyroid dysfunction(TSH<0.34μmol/L or TSH>5.60μmoL/L),of which28cases were hyperthyroidism(TSH=0.31moL/L),and the incidence was0.35%;Of the144cases with hypothyroidism(TSH=5.73moL/L),the incidence was1.8%.All of the61cases of abnormal thyroid function were treated with intervention and111were untreated.Compared with the women who received the intervention and the women who refused to accept the intervention,it was found that the age status of the two groups was basically the same,but the majority of the patients without intervention had hypothyroidism(P<0.05).In the aspects of pregnancy rate,abortion rate,fetal malformation rate,neonatal thyroid disease incidence and postpartum depression,women with normal thyroid function were significantly better(P<0.01),the differences were significant.There were significant differences in pregnancy rate and incidence of neonatal thyroid disease between patients with treatment and patients with rejection of intervention(P<0.01).Conclusion It is of great significance for the determination of thyroid hormone level before pregnancy and for the early intervention of thyroid disease in women of childbearing age,which is worthy of clinical reference and reference.
作者
王瑛
潘锦涛
宋秀玲
WANG Ying;PAN Jintao;SONG Xiuling(Shenzhen Baoan District Family Planning Hospital,Shenzhen 518100,China)
出处
《中国医药科学》
2018年第4期86-89,共4页
China Medicine And Pharmacy
基金
广东省深圳市知识创新计划基础研究项目(JCYJ20150402100142485)
关键词
育龄妇女
孕前甲状腺激素水平监测
孕前早期干预
甲状腺疾病
Women of childbearing age
Pre-pregnancy thyroid hormone level monitoring
Pre-pregnancy intervention
Thyroid disease
