摘要
目的:探讨甲状腺微小乳头状癌(PTMC)患者临床病理特征与中央区淋巴结转移的关系。方法:回顾性分析413例PTMC患者的临床病理特征,应用χ~2检验和多因素Logistic回归模型分析中央区淋巴结转移的危险因素。结果:413例PTMC患者中央区淋巴结转移率为57.9%(239例)。单因素分析显示,男性、年龄<45岁、肿瘤直径>5 mm、肿瘤位于甲状腺下极、多灶性、包膜侵犯等均与中央区淋巴结转移有关(P<0.05)。多因素分析显示,年龄<45岁、包膜侵犯是PTMC中央区淋巴结转移的独立危险因素(P<0.01)。结论:具备年龄<45岁、包膜侵犯等特征的PTMC患者,较易发生中央区淋巴结转移,建议行预防性中央区淋巴结清扫。
Objective:To explore the correlation between the clinical features of papillary thyroid microcarcinoma(PTMC)and central compartment lymph node(CCLN)metastasis in PTMC.Methods:Data of413patients with PTMC were retrospectively analyzed.Chi-square test and multivariate logistic regression analysis were used to study the risk factors.Results:CCLN metastasis were found in239of413patients(57.9%).The univariate analysis showed that male gender,age under45years,tumor size bigger than5mm,tumor location in the lower third of the thyroid,multifocal,capsular invasion were significantly associated with CCLN metastasis(P<0.05).The multivariate analysis showed that the age below45years and capsular invasion were independently correlated with CCLN metastasis(P<0.01).Conclusion:A prophylactic neck dissection of the central compartment should be considered particularly in PTMC patients with age below45years and capsular invasion
作者
王猛
魏玺
郑向前
高明
WANG Meng;WEI Xi;ZHENG Xiang-qian;GAO Ming(Department of Thyroid and Neck Tumor, Cancer Hospital ,Tianjin Medical University,National Clinical Research Center for Cancer,Tianjin Key Laboratory of Cancer Prevention and Therapy,Tianjin’s Clinical Research Center for Cancer,Tianjin 300060,China;Department of Ultrasound Diagnosis and Treatment, Cancer Hospital ,Tianjin Medical University,Tianjin 300060,China)
出处
《天津医科大学学报》
2018年第2期138-141,共4页
Journal of Tianjin Medical University
基金
国家自然科学基金资助项目(81472580)
关键词
甲状腺微小乳头状癌
中央区淋巴结
转移
危险因素
papillary thyroid microcarcinoma
central compartment lymph node
metastasis
risk factors
