摘要
目的:观察辅酶Q10(Co Q10)对大鼠实验性牙周炎的影响作用。方法:选取雄性SD大鼠168只,随机分为正常组(N)、模型组(P)、替硝唑组(T)、维生素C组(VC)、辅酶Q10低、中、高剂量组(LQ、MQ、HQ)。灌胃给药第2、4、6周,随机抽取8只,采血检测血浆中IL-1β、TNF-α、PGE2、SOD、GSH-Px、MDA水平;测量大鼠牙槽骨附着丧失,并行HE染色、TRAP染色。结果:Co Q10可降低血浆中IL-1β、TNF-α、PGE2水平;增加SOD、GSH-Px活力,减少MDA含量。结论:Co Q10可抑制和缓解大鼠实验性牙周炎。
Objective To investigate the effect of coenzyme Q10(CoQ10)on experimental periodontitis in rats.Methods 168 healthy SD rats were randomly divided into normal group(n),model group(P),tinidazole group(T)and vitamin C group(VC),coenzyme Q10 low,medium,high dose group(LQ,MQ,HQ).Intragastric administration for week 2,4,6,8 rats were randomly selected to detect IL-1β、TNF-α、PGE2、SOD、GSH-Px、MDA of their peripheral blood;The ABL value was detected,and the HE staining and TRAP staining were performed.Results CoQ10 could significantly decrease the levels of IL-1β,TNF-α,PGE2;the activity of GSH-Px and SOD increase more,and MDA decrease.Conclusion CoQ10 can inhibit the experimental periodontitis in rats.
作者
黄捷
李庆华
任晓斌
杨晶津
陈兴
唐丽
唐军
汪显国
HUANG Jie;LI Qinghua;REN Xiaobin;YANG Jingjin;CHEN Xing;TANG Li;TANG Jun;WANG Xianguo(Graduate School of Kunming Medical University,Kunming 650500,China;HongyunHonghe Tobacco(Group)Co.,Ltd.,Kunming 650231,China;Technology Center of China Tobacco Yunnan Industrial Co.,Ltd.,Kunming 650231,China;Affiliated Hospital of Kunming Medical University,Kunming 650500,China)
出处
《中国民族民间医药》
2018年第5期25-32,36,共9页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
云南省科技厅-昆明医科大学联合专项重点项目(2012FB008)
昆明医科大学附属口腔医院横向项目(HYHH2013HX06)
国家自然科学基金(81060086)
关键词
辅酶Q10
牙周炎
氧化应激
Coenzyme Q10
Periodontitis
Oxidative Stress
