摘要
目的分析2型糖尿病肾病用药规律,为临床治疗糖尿病肾病及科学研究提供理论依据。方法收集空军总医院中医科住院的2型糖尿病肾病60例的病历资料,采用频数分布分析、关联规则分析等数据挖掘方法对其中的60首有效方剂进行分析,探讨2型糖尿病肾病用药规律。结果收录2型糖尿病肾病中药方剂60首,使用中药143种,用药频率排在前15位的中药从高到低依次是生黄芪、茯苓、生地黄、泽泻、山药、山萸肉、牡丹皮、当归、石韦、泽兰、水红花子、芡实、党参、地龙、熟地黄;常用方剂有:六味地黄汤、参芪地黄汤、萆薢分清饮等;药物的分类频次较多的有补虚药、利水渗湿药、活血化瘀药、清热药等;常用药物归经频次最多的脾、肾经;两药关联组合按支持度高低依次有泽泻→茯苓、茯苓→生黄芪、生地黄→生黄芪等,三药关联组合按支持度高低依次有茯苓+泽泻→生黄芪、山茱萸→生黄芪+泽泻、茯苓+泽泻→山茱萸等。结论糖尿病肾病用药以补益、利水渗湿、活血、清热之品居多,药物归经多以脾、肾两经为主,药物之间关联多以参芪地黄汤的组方为主;治疗按分期论治,以滋肾、活血通络为大法,兼以清热、利湿、解毒等治疗,活血通络应贯穿病程的始终。
Objective To analyze medication law of type 2 diabetic nephropathy in order to provide theoretical basis for clinical treatment and scientific research of diabetic nephropathy.Methods Clinical data of 60 patients with type 2 diabetic nephropathy was collected,and investigated methods for clinical data such as frequency distribution and association rule analysis were used to analyze the firstly effective prescriptions in the 60 patients and investigate medication law of type 2 diabetic nephropathy.Results A total of 60 prescriptions of traditional Chinese drug(TCD)for type 2 diabetic nephropathy were collected,which had involved 143 kinds of TCD.The top frequency medications of 15 kind of TCD were Astragalus,Fuling,Radix Rehmanniae,Alisma Orientalis,Yam,Cornus,Tree Peony Bark,Angelica,Pyrrosia Lingua,Eupatorium,Fructus Polygoni Orientalis,Euryale Ferox,Dangshen,Earthworm and Prepared Rehmannia Root in turn.Common prescriptions were Liuwei Dihuang decoction,Shenqi Dihuang decoction,Bixie Fenqing decoction and so on.The commonly used medicines were tonic drugs,diuretics for eliminating dampness,drug for invigorating blood circulation and eliminating stasis and antipyretic drugs.Main drug effects were in spleen and kidney.The highly frequent use of two kinds of drug combinations were Alisma Orientalis→Fuling,Fuling→Astragalus,Radix Rehmanniae→Astragalus and so on.The highly frequent use of three kinds of drug combinations were Fuling+Alisma Orientalis→Astragalus,Cornus→Astragalus+Alisma Orientalis,Fuling+Alisma Orientalis→Cornus and so on.Conclusion Drugs in treatment of diabetic nephropathy mainly are tonic,removing dampness and promoting diuresis,activating blood circulation and clearing-heat drugs,and drug effects mainly are in spleen and kidney.Drug combinations are mainly based on Shenqi Dihuang decoction.The treatment of diabetic nephropathy should be step by step,Nourishing kidney and promoting blood circulation to remove meridian obstruction are the main treatment,and clearing-heat,eliminating dampness and detoxication are added at appropriate time.Promoting blood circulation to remove meridian obstruction should be always given during the course of disease.
作者
郭燕周
张蕾
王小雨
马建伟
GUO Yanzhou;ZHANG Lei;WANG Xiaoyu;MA Jianwei(Department of Traditional Chinese Medicine,General Hospital of PLA Air Force,Beijing 100142,China;People Hospital of Tanghe County,Tanghe,Henan 473400,China;Peoples Hospital of Zhucheng,Zhucheng,Shandong 262200,China)
出处
《解放军医药杂志》
CAS
2018年第1期9-12,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
首都医学发展基金(SF-2009-I-13)
关键词
糖尿病肾病
中药疗法
辨证论治
活血通络
Diabetic nephropathies
Drug therapy
Syndrome differ treatment
Activat blood dred collater
