摘要
目的研究尿液中中性粒细胞明胶酶相关载脂蛋白(NGAL)、肝型脂肪酸结合蛋白(L-FABP)、肾损伤分子(KIM-1)联合检测对儿童早期急性肾衰竭的诊断价值。方法选择2015年9月至2016年9月期间在该院ICU治疗的脓毒血症患儿128例作为研究对象,根据患儿是否发生急性肾损伤(AKI)分为AKI组和对照组,其中发生AKI的26例患儿作为AKI组,未发生AKI的102例患儿作为非AKI组;并以同期60例健康儿童作为健康对照组,对两组患儿尿液NGAL、L-FABP、KIM-1水平进行检测。结果AKI组患儿尿液NGAL、L-FABP、Kim-1水平明显高于非AKI组和健康对照组;6h时尿中NGAL、L-FABP、Kim-1联合检测效能最高,联合检测的敏感性、特异性、阳性预测值、阴性预测值分别为86.7%、97.8%、78.3%、98.7%,明显高于尿中NGAL、L-FABP、Kim-1的诊断效能;将6h尿液中NGAL、L-FABP、KIM-1水平与48h患儿肌酐和GFR水平进行相关性分析发现,早期患儿尿液中NGAL、L-FABP、KIM-1水平与48h患儿肌酐和GFR水平均呈正相关。结论尿液中NGAL、L-FABP、KIM-1联合检测对诊断儿童AKI意义重大,值得临床推广运用。
Objective To investigate the diagnostic value of combined detection of NGAL,L-FABP and KIM-1 in urine for early acute kidney injury in children.Methods 128 cases sepsis patients in our hospital during ICU from September 2015 to September 2016 were enrolled in the study,according to the occurrence of acute renal injury(AIK)were divided into observation group and control group,the incidence of AKI in 26 cases as the observation group,102 cases without AKI as control group;the content of urine collected from two groups of children,NGAL L-FABP,KIM-1.Results In AKI group 6 h NGAL,L-FABP,Kim-1 in urine increased significantly higher than that of the other time points and non AKI group level,significant difference was statistically significant;6h NGAL,L-FABP,Kim-1 in urine combined detection efficiency is highest,sensitivity,specificity and positive pre detection value and negative predictive value were measured 86.7%,97.8%,78.3%a,98.7%a,was significantly higher than the diagnostic efficacy of urinary NGAL,L-FABP,Kim-1;6h,L-FABP,NGAL in the urine level of KIM-1 and 48h in patients with creatinine and GFR levels of correlation analysis found that in children with early urinary NGAL,L-FABP,KIM-1 and 48h in children with creatinine and GFR levels were positive related.Conclusion The detection of NGAL,L-FABP and KIM-1 in urine is of great significance in the diagnosis of AKI in children,which is worthy of clinical application.
作者
王钊华
董自杰
韩彦洁
张静
祁洁
WANG Zhaohua;DONG Zijie;HAN Yanjie;ZHANG Jing;QI Jie(Department of Clinical Laboratory,the Fourth Hospital of Shijiazhuang, Shijiazhuang,Hebei 050000,China;Department of Clinical Laboratory,the Third Hospital of Shijiazhuang,Shijiazhuang,Hebei 050011,China;Prenatal Diagnosis Center,the Fourth Hospital of Shijiazhuang,Shijiazhuang,Hebei 050000,China;Department of Clinical Laboratory,the First Hospital of Shijiazhuang,Shijiazhuang,Hebei 050000,China)
出处
《国际检验医学杂志》
CAS
2018年第3期286-288,292,共4页
International Journal of Laboratory Medicine
基金
石家庄市科学研究与发展计划项目(151461113)
