摘要
目的:研究腔隙性脑梗死患者颅内动脉钙化程度与粥样斑块性质、氧化应激反应的相关性。方法:选择2014年6月~2017年4月期间在我院诊断为腔隙性脑梗死的患者作为研究的LI组,行CTA检查并判断颅内动脉钙化程度;另取同期在我院体检的健康者作为研究的对照组。取两组受试者的血清并检测斑块性质及氧化应激反应相关生化指标的含量。结果:LI组患者血清中Hcy、hs-CRP、MMP3、MMP9、ox-LDL、ET、TRAIL的含量显著高于对照组,NO、MT的含量显著低于对照组;LI组中轻度钙化和重度钙化患者血清中Hcy、hs-CRP、MMP3、MMP9、ox-LDL、ET、TRAIL的含量显著高于无钙化患者,NO、MT的含量显著低于无钙化患者,重度钙化患者血清中Hcy、hs-CRP、MMP3、MMP9、ox-LDL、ET、TRAIL的含量显著高于轻度钙化患者,NO、MT的含量显著低于轻度钙化患者。结论:腔隙性脑梗死患者颅内动脉钙化程度的加重与粥样斑块性质改变、氧化应激反应激活密切相关。
Objective:To study the correlation of intracranial artery calcification with atherosclerotic plaque properties and oxidative stress response in patients with lacunar infarction Methods:Patients who were diagnosed with lacunar infarction in the hospital between June 2014 and April 2017 were selected as the LI group of the research,and CTA was conducted to judge the intracranial calcification degree;healthy subjects who received physical examination in the Third People's Hospital of Chengdu during the same period were selected as the control group of the research Serum was collected from the two groups to determine the plaque properties and the oxidative stress response related biochemical index levels Results:Serum Hcy,hs CRP,MMP3,MMP9,ox LDL,ET and TRAIL levels of LI group were greatly higher than those of control group whereas NO and MT levels were greatly lower than those of control group;serum Hcy,hs CRP,MMP3,MMP9,ox LDL,ET and TRAIL levels of LI group of patients with mild calcification and severe calcification were greatly higher than those of patients without calcification whereas NO and MT levels were greatly lower than those of patients without calcification,and serum Hcy,hs CRP,MMP3,MMP9,ox LDL,ET and TRAIL levels of LI group of patients with severe calcification were greatly higher than those of patients with mild calcification whereas NO and MT levels were greatly lower than those of patients with mild calcification Conclusion:The increase of intracranial artery calcification in patients with lacunar infarction is closely related to the changes of atherosclerotic plaque properties and the activation of oxidative stress response
作者
陈昱璨
周瀚
邹佳瑜
杨训永
Chen Yu can;Zhou Han;Zou Jia yu;Yang Xun yong(Department of Radiology,Chengdu Third People's Hospital in Sichuan Province,Chengdu,Sichuan Province,610000;Department of Neurology,Chengdu Third People's Hospital in Sichuan Province,Chengdu,Sichuan Province,610000)
出处
《海南医学院学报》
CAS
2018年第3期413-416,共4页
Journal of Hainan Medical University
基金
成都市卫生局2015年科研课题2015116~~
