摘要
Eph受体及其膜结合型配体Ephrin与血管发生、细胞迁移、神经元定位、胚胎发育等密切相关,越来越多的研究表明它们参与各种癌症的发生和发展。本文重点讨论Eph受体家族参与肺癌组织形成和发展,以及转移、耐药等方面的机制,及其作为肺癌靶向治疗靶点的可能性。
The Eph receptors and their ligand Ephrins are closely associated with angiogenesis,cell migration,neuronal localization and embryonic development.More and more studies have shown that the Eph receptor and Ephrins are involved in the occurrence and development of various cancers.In this article,we will focus on the Eph receptor family involved in the formation and development of lung cancer and metastasis,drug resistance and other mechanisms as well as their potential as targeted therapy of lung cancer.
作者
何佳雯
陈公琰
HE Jiawen;CHEN Gongyan(Harbin Medical University Cancer Hospital,Harbin 150081,China)
出处
《实用肿瘤学杂志》
CAS
2018年第2期164-168,共5页
Practical Oncology Journal
