摘要
目的观察芪苈强心胶囊对急性心肌梗死(AMI)患者经皮冠状动脉动脉介入(PCI)术后远期心功能及支架内再狭窄的影响。方法选择2014年8月—2016年7月河北省邢台市第三医院心内科收治AMI患者153例作为研究对象,采用随机数字表法分为观察组77例和对照组76例。对照组患者给予急性心肌梗死的常规治疗;观察组在常规治疗基础上加用芪苈强心胶囊。术前及治疗1年后比较2组患者碎裂QRS波检测率、心脏超声、血清基质金属蛋白酶-9(MMP-9)、肿瘤坏死因子-α(TNF-α)、一氧化氮(NO)浓度变化及术后1年后支架内再狭窄情况。结果治疗1年后,2组患者碎裂QRS波检测率比较差异无统计学意义(χ~2=1.467,P=0.099);2组左室射血分数(LVEF)及室间隔厚度比较差异有统计学意义(t=4.150、1.995,P=0.000、0.041),左室舒张末期内径比较差异无统计学意义(t=1.236,P=0.304);观察组血清MMP-9、TNF-α均较对照组明显降低(t=3.034、3.050,P=0.005、0.005),而NO较对照组明显升高(t=2.871,P=0.008);观察组患者支架内再狭窄发生率明显低于对照组(χ~2=4.899,P=0.045)。结论 AMI患者PCI术后应用芪苈强心胶囊可进一步改善远期心功能,并且可减少支架内再狭窄的发生。
Objective To observe the long term effect of Qiliqiangxin capsule in patients with acute myocardial infarction(AMI).Methods A total of 153 patients with AMI in the Department of Cardiology of Xingtai 3rd Hospital between August 2014 and July 2016 were randomly divided into the observation group(77 cases)and the control group(76 cases),both groups were treated with standardized treatment of AMI.In addition to standard therapy,Qiliqiangxin capsule was received in observation group.The serum matrix metalloproteinase 9(MMP 9),tumor necrosis factorα(TNF-α),nitric oxide(NO)concentration,the occurrence dynamics of fQRS were compared.The left ventricular end diastolic diameter(LVEDD),left ventricular systolic function indicator(LVEF),interventricular septum dimensions(IVSd)and the occurrence dynamics of in-stent restenosis were also compared.Results There were statistically significant differences of the serum MMP 9,TNF-α,NO concentration after one year treatment between the two groups(t=3.034,t=3.050,t=2.871,P=0.005,P=0.005,P=0.008).There was no statistically significant differences of the detection rate of fQRS after one year treatment between the two groups(χ2=1.467,P=0.099);There were statistically significant differences of the LVEF,IVSd after one year treatment between the two groups(t=4.150,t=1.995,P=0.000,P=0.041).There was no statistically significant differences of the LVEDD after one year treatment between the two groups(t=1.236,P=0.304).Rates of in-stent restenosis was lower in the observation group than in the control group(χ2=4.899,P=0.045).Conclusion For patients with AMI after PCI,Qiliqiangxin capsule can further improve the heart function,and can reduce the occurrence of in-stent restenosis.
作者
陈要起
穆金兴
陈洪波
李雪霞
李延鑫
曹亚冰
齐丽平
朱凌凌
CHEN Yaoqi;MU Jinxing;CHEN Hongbo;LI Xuexia;LI Yanxin;CAO Yabin;QI Liping;ZHU Lingling(Department of Cardiology,Xingtai Third Hospital,Xingtai 054000,China)
出处
《疑难病杂志》
CAS
2018年第4期334-338,共5页
Chinese Journal of Difficult and Complicated Cases
关键词
芪苈强心胶囊
心肌梗死
心功能
支架内再狭窄
Qiliqiangxin capsule
Myocardial infarction
Cardiac function
Restenosis
