摘要
原发性十二指肠腺癌(PDA)是一种少见的侵袭性较高的消化道恶性肿瘤,其发病率有逐年增加的趋势。临床表现缺乏特异性,早期诊断困难,一旦发现或确诊时,多数患者已出现了局部侵犯或远处转移。治疗往往倾向于积极的手术切除,辅助化疗和放疗是复发风险高者综合治疗的重要组成部分,分子靶向治疗尚处于探索阶段。目前术后最佳的辅助治疗方案尚未明确,早期诊断和治疗对患者的预后具有重要意义。本文就PDA的流行病学、危险因素、诊治和预后的研究进展作一综述。
Primary duodenal adenocarcinoma(PDA)is a rare but aggressive digestive tract malignancy,and its incidence is increasing in recent years.Early diagnosis of PDA is challenging due to nonspecific symptoms.Hence,it is often detected at an advanced stage.Treatment strategies tends to favor aggressive surgical resection.Adjuvant chemotherapy and radiation are important components of multi-modality treatment for patients with high risk of recurrence,and molecular targeted therapy is still in the exploratory stage.The best adjuvant therapy after operation is not yet clear.Early diagnosis and treatment is of great significance for prognosis.This article reviewed advances in epidemiology,risk factors,diagnosis,treatment and prognosis of PDA.
作者
史玉雪
陈卫昌
SHI Yuxue;CHEN Weichang(Department of Gastroenterology,the First Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province(215000))
出处
《胃肠病学》
2018年第6期370-373,共4页
Chinese Journal of Gastroenterology
关键词
十二指肠肿瘤
诊断
治疗
预后
Duodenal Neoplasms
Diagnosis
Therapy
Prognosis
