摘要
目的探讨阴道微环境改变与高危型人乳头瘤病毒(HR-HPV)感染的相关性。方法选择2016年1月至2017年5月来东莞市塘厦医院妇科门诊就诊的宫颈细胞学检测阴性的患者2 945例,分析其阴道微环境改变与HR-HPV感染的相关性。结果 2 945例标本中阴道微环境改变1 957例(66.45%),其中HRHPV感染384例(19.62%),与阴道微环境正常者比较HR-HPV感染率差异有统计学意义(P<0.05)。需氧菌性阴道炎(AV)302例(15.43%),细菌性阴道炎(BV)578例(29.54%),外阴阴道假丝酵母菌性阴道炎(VVC)276例(14.10%),滴虫性阴道炎(TV)225例(11.50%),单纯过氧化氢(H_2O_2)缺乏246例(12.57%),单纯H_2O_2和白细胞酯酶(LE)阳性330例(16.86%),混合性阴道炎439例(22.43%),AV、BV、VVC、TV、单纯H_2O_2缺乏、单纯H_2O_2和LE阳性、混合性阴道炎中HR-HPV感染分别为78例(25.83%)、184例(31.86%)、83例(30.11%)、56例(24.92%)、62例(25.24%)、94例(28.48%)、215例(48.97%),以上各类型与阴道微环境正常者HR-HPV感染率比较差异均有统计学意义(P<0.05);BV、VVC与其他类型阴道微环境改变者HR-HPV感染率差异有统计学意义(P<0.05),AV、TV与其他类型阴道微环境改变组HR-HPV感染率差异无统计学意义(P>0.05);混合性阴道炎与各类HR-HPV感染率比较差异均有统计学意义(P<0.05)。结论 AV、BV、VVC、TV、单纯H_2O_2缺乏、单纯H2O2和LE阳性与HR-HPV感染有关。
Objective To investigate the correlation between the change of vaginal microenvironment and high-risk human papillomavirus(HR-HPV)infection.Methods From January 2016 to May 2017,2 945 patients with negative cytology of cervix in Tangxia gynecology clinic of Dongguan hospital were selected,and the correlation between the change of vaginal microenvironment and HR-HPV infection was analyzed.Results There were 1 957 cases of vaginal micro environment change in 2 945 cases,accounting for 66.45%.Aerobic vaginitis(AV)accounted for 302 cases(15.43%),bacterial vaginosis(BV)accounted for 578 cases(29.54%),vulvovaginal candidiasis(VVC)accounted for 276 cases(14.10%),trichomonas vaginitis(TV)accounted for 225 cases(11.50%),pure hydrogen peroxide(H 2O 2)deficiency accounted for 246 cases(12.57%)simple,H 2O 2 and white blood cell lipase(LE)was 330 cases(16.86%),mixed vaginitis accounted for 439 cases(22.43%),and HR-HPV infection were 78 cases(25.83%),184 cases(31.86%),83 cases(30.11%),56 cases(24.92%),62 cases(25.24%),94 cases(28.48%),215 cases(48.97%);each group above and the vaginal microenvironment of normal group(normal group)HR-HPV infection rate was statistically significant(P<0.05);BV,VVC and other types of vaginal micro environment change was statistically significant(P<0.05).Differences of infection rates of AV,TV and other types of vaginal micro environment change patients had no statistically significance(P>0.05);mixed vaginitis and HR-HPV infection rate were statistically significance(P<0.05).Conclusion AV,BV,VVC,the TV,H 2O 2,H 2O 2 and simple lack of pure LE positive were correlated with HR-HPV infection.
作者
钟阳青
陈艳清
肖翔
郭馥艳
闵琴琴
ZHONG Yangqing;CHEN Yanqing;XIAO Xiang;GUO Fuyan;MIN Qinqin(Department of Clinical Laboratory,Tangxia Hospital,Dongguan,Guangdong 523722,China;Department of Gynaecology,Tangxia Hospital,Dongguan,Guangdong 523722,China;Department of Pathology,Shenzhen TCM Hospital,Shenzhen,Guangdong 518033,China)
出处
《检验医学与临床》
CAS
2018年第13期1960-1962,共3页
Laboratory Medicine and Clinic
关键词
阴道微环境
人乳头瘤病毒感染
宫颈癌
vaginal microenvironment
human papilloma virus infection
cervical cancer
