摘要
Metformin(MET),which is a biguanide commonly used as first line of treatment for type II diabetes,has recently sparked interest as a potential anticancer agent.But in previous studies,we found that metformin could induce great differences of growth inhibition in different cancer cells.To explore the radiosensitivity effect of MET in different NSCLC genotypes,we used lines that represent common histologies and mutation profile of NSCLC(A549 adenocarcinoma:LKB1-deficient(nonsense mutation of codon 37 leading to stop codon),K-Ras G12Sactivating mutant,p53-WT;H1299 adenocarcinoma:LKB1-WT,p53-deficient(TP53 partial deletion)and H1650 adenocarcinoma:LKB1-WT,p53-WT,EGFR-mutation(theΔE746-E750 deletion mutant).
