摘要
目的分析阿尔茨海默病患者血尿酸水平变化,探讨血尿酸在AD患者发病机制的作用。方法收集2013年1月~2017年4月我科收治的AD患者94例为AD组,同时收集体检中心同年龄段、性别比例构成相似的健康体检人群127例为健康对照组。对两组尿酸水平进行检测分析。结果 AD组血尿酸水平低于健康对照组,差异有统计学意义(P<0.01);健康对照组女性血尿酸水平低于男性,差异有统计学意义(P<0.01);AD组女性血尿酸水平低于男性,差异有统计学意义(P<0.05)。结论血尿酸在AD发病机制中起重要作用,与AD的发生发展密切相关,血尿酸可能为AD的保护因素之一。
Objective To analyze the changes of serum uric acid in patients with Alzheimer's disease and to explore the role of serum uric acid in the pathogenesis of AD.Methods From January 2013 to April 2017,94 patients with AD in our department were enrolled as AD group,and 127 healthy people with similar sex ratio in the same age group were collected as healthy control group.The two groups of uric acid levels were analyzed.Results The level of serum uric acid in AD group was lower than that in healthy control group,the difference was statistically significant(P<0.01);The level of serum uric acid in female healthy control group was lower than that in male group,the difference was statistically significant(P<0.01).The level of serum uric acid in female AD group was lower than that in male group,the difference was statistically significant(P<0.05).Conclusion Serum uric acid plays an important role in the pathogenesis of AD and is closely related to the occurrence and development of AD.Serum uric acid may be one of the protective factors of AD.
作者
刘璐
秦新月
LIU Lu;QIN Xin-yue(Department of Neurology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
出处
《医学信息》
2018年第2期96-97,100,共3页
Journal of Medical Information
关键词
阿尔茨海默病
血尿酸
氧化应激
发病机制
保护因素
Alzheimer's disease
Blood uric acid
Oxidative stress
Pathogenesis
Protection factors
