摘要
目的:探讨急性下肢深静脉血栓形成(DVT)患者急性期血中内皮素-1(ET-1)、5-羟色胺(5-HT)水平、相关性及临床意义。方法:收集2016-12~2017-07佳木斯大学附属第一医院血管外科急性期下肢深静脉血栓形成患者52例及同期健康体检者30例做为对照组,患者于入院当天治疗前采血,用酶联免疫吸附方法(ELISA)检测血浆ET-1、5-HT水平,将两组上述指标进行组间比较及相关性分析。结果:患者ET-1水平较对照组显著增高(P<0.01)、5-HT水平明显高于对照组(P<0.01),且二者存在正相关。结论:急性下肢深静脉血栓形成患者ET-1和5-HT水平较对照组增高,ET-1联合5-HT检测可做为早期诊断和早期预测DVT的标志物,且二者的相互作用可能对DVT发病机制有重要意义。
Objective:To explore the correlation and clinical significance between ET-1 and 5-HT in patients with deep venous thrombosis of lower extremities in acute stage.Methods:A total of 52 patients with acute deep venous thrombosis and 30 healthy volunteers as a control group were recruited from department of vascular Surgery,in the First Hospital of Jiamusi University from December 2016 to July 2017.The blood samples of patients were collected before treatment,and the level of plasma ET-1 and 5-HT were detected by ELISA method.We compared the two groups of indicators and analyzed the correlation.Results:The levels of ET-1 and 5-HT in patients with DVT were higher than those in the control group(P<0.01).There was positive correlation between ET-1 and 5-HT.Conclusion:The levels of ET-1 and 5-HT in patients with DVT were higher than those in the control group.ET-1 combined with 5-HT detection can be used as a marker for early diagnosis and early prediction of DVT.The interaction between the two factors may be of great significance to the pathogenesis of DVT.
作者
韦利
金松
程明勋
孙瑶
杨婷
WEI Li;JIN Song;CHENG Ming-xun;SUN Yao;YANG Ting(Department of Vascular Surgery,The First Hospital of Jiamusi University,Jiamusi 154003,China)
出处
《黑龙江医药科学》
2018年第3期60-62,共3页
Heilongjiang Medicine and Pharmacy
基金
佳木斯大学研究生科技创新项目
编号:YM2016_027
