摘要
外泌体是来源于细胞的直径在40~120 nm的膜性囊泡,其内含蛋白质、脂质、mRNA和miRNA,可以传递生物活性物质至靶细胞,参与细胞之间的信号转导,影响细胞的生物学行为。最新研究发现由于胶质瘤外泌体在脊髓液中可检测的特点,其可以作为生物学标志物,在疾病的诊断和预后评估中发挥重要作用。本文对外泌体的构成、生物学特性以及在胶质瘤临床治疗中的最新研究进展进行综述。
Exosomes are membrane-derived vesicles,which measures 40-120 nm in diameter.It contains variety of proteins,lipids,mRNA and miRNA which may convey bioactive substance to target cell,involve in signal transduction,and thereby influence the biological behavior of cell.Recent studies have shown that the presence of exosome in glioma can be detected in the spinal fluid,and thus exosomes can act as biomarker and play a vital role in diagnosis and prognosis evaluation.In this review,we summarized the formation,biological characteristics and recent advances of exosome in clinical treatment of glioma.
作者
李晨龙
王斯文
侯伟良
郑宏山
梁鹏
LI Chen-Long;WANG Si-Wen;HOU Wei-Liang;ZHENG Hong-Shan;LIANG Peng(Department of Neurosurgery,Cancer Hospital,Harbin Medical University,Harbin 150001,China)
出处
《转化医学电子杂志》
2018年第7期44-48,共5页
E-Journal of Translational Medicine
基金
哈尔滨医科大学创新科学研究基金(2016LCZX74)
关键词
外泌体
胶质瘤
诊断
治疗
exosomes
glioma
diagnosis
treatment
