摘要
目的研究血清Ig G、Ig M及Ig A的检测对慢性乙肝所致的肝衰竭患者预后的意义。方法本研究分别以56例的慢性乙肝所致的肝衰竭患者(肝衰竭组)及56名心、肝、肾功能正常的健康人群(健康组)为研究对象,于清晨空腹情况下在无菌环境中进行静脉采血5 ml,采用免疫混浊法对两组人群的Ig G、Ig M及Ig A水平进行检测。并比较健康组和肝衰竭组人群的Ig G、Ig M及Ig A水平是否具有差异性,以及比较早期肝衰竭患者组和中晚期肝衰竭患者组人群的Ig G、Ig M及Ig A水平是否具有差异性。结果本研究通过分析健康组和肝衰竭组发现:肝衰竭组的Ig G平均值为(15.34±3.11),健康组为(11.36±2.11),肝衰竭组高于健康组,差异具有统计学意义(P<0.01);肝衰竭组的Ig A平均值为(2.84±0.72),健康组为(1.88±0.63),肝衰竭组高于健康组,差异具有统计学意义(P<0.01);肝衰竭组的Ig A平均值为(2.79±0.65),健康组为(1.60±0.49),肝衰竭组高于健康组,差异具有统计学意义(P<0.01)。通过分析不同程度的肝衰竭组发现:早期肝衰竭组组的Ig G检测结果为(12.56±3.02),中晚期肝衰竭组的Ig G检测结果为(15.36±2.09),差异具有统计学意义(P<0.01);早期肝衰竭组组的Ig A检测结果为(2.62±0.74),中晚期肝衰竭组的Ig A检测结果为(3.02±0.61),差异具有统计学意义(P<0.05);早期肝衰竭组的Ig M检测结果为(2.01±0.63),中晚期肝衰竭组的Ig M检测结果为(2.65±0.58),差异具有统计学意义(P<0.01)。结论血清Ig G、Ig M及Ig A检测对慢性乙肝所致的肝衰竭患者具有重要意义,并且可以反映患者的肝衰竭程度,即Ig G、Ig M及Ig A水平越高,肝衰竭程度越重,可以作为其肝功受损的指标。
Objective To study detection of serum IgG,IgM and IgA in patients with liver failure caused by chronic hepatitis B.Methods In this study,56 cases of chronic hepatitis B caused by liver failure(liver failure group)and 56 healthy people(healthy group)with normal function of heart,liver and kidney were studied.Venous blood sampling was performed in a sterile environment in the morning empty stomach,and the levels of IgG,IgM and IgA in two groups of two groups were examined by immunological turbidity.Test.Whether the levels of IgG,IgM and IgA in the healthy group and the liver failure group were different,and whether the levels of IgG,IgM and IgA were different in the patients with early liver failure and in the middle and late stage of liver failure.Results By analyzing the health group and the liver failure group,the average value of IgG in the liver failure group was(15.34±3.11),the health group was(11.36±2.11),and the liver failure group was higher than the healthy group.The difference was statistically significant(P<0.01).The average IgA value of the liver failure group was(2.84±0.72),the health group was(1.88±0.63),the liver failure group was higher than the healthy group,the difference was statistically significant(P<0.01),the average value of IgA in the liver failure group was(2.79±0.65),the health group was(1.60±0.49),and the Gao Yujian Kang group of the liver failure group was statistically significant(P<0.01).The results of IgG detection in the group of early liver failure were(12.56±3.02),and the results of IgG detection in the middle and late stage liver failure group were(15.36±2.09),and the difference was statistically significant(P<0.01).The results of IgA detection in the early liver failure group were(2.62±0.74),and the middle and late stage liver failure group was(2.62±0.74).The results of IgA detection were(3.02±0.61),and the difference was statistically significant(P<0.05);the results of IgM detection in the early liver failure group were(2.01±0.63),and the results of IgM detection in the middle and late stage liver failure group were(2.65±0.58),and the difference was statistically significant(P<0.01).Conclusion The detection of serum IgG,IgM and IgA is of great significance to the patients with chronic hepatitis B caused by liver failure,and it can reflect the degree of liver failure,that is,the higher the level of IgG,IgM and IgA,the more severe the degree of liver failure,which can be used as the index of the damage of liver function.
作者
陈少
胡娟娟
周丽
Chen Shao;Hu Juanjuan;Zhou Li(Department of Laboratory,Siyang Kangda Hospital,Siyang County,Suqian,Jiangsu,223700,China)
出处
《当代医学》
2018年第22期47-49,共3页
Contemporary Medicine
