摘要
目的探讨帕金森病患者接受盐酸美金刚治疗的临床效果。方法选取2016年8月—2017年8月我院接收的帕金森病患者60例作为研究对象。将全部患者分为参照组与实验组,每组均有30例。参照组患者采用盐酸多奈哌齐治疗,实验组患者采用盐酸美金刚治疗,两组患者的临床治疗不良反应情况进行比较分析。结果实验组患者的不良反应发生率为6.67%,参照组患者的不良反应发生率为26.67%,两组对比,差异具有统计学意义(P<0.05)。治疗前,两组患者的MoCA、MMSE评分对比,差异无统计学意义(P>0.05);治疗后,实验组患者的MoCA、MMSE评分高于参照组,差异具有统计学意义(P<0.05)。结论帕金森病患者接受盐酸美金刚治疗的效果显著,对患者生存情况有改善效果。
Objective To investigate the clinical effect of memantine hydrochloride in patients with Parkinson's disease.Methods 60 cases of Parkinson's disease admitted to our hospital from August 2016 to August 2017 were selected as the research objects.All patients were divided into the reference group and the experimental group,with 30 cases in each group.The patients in the reference group were treated with donepezil hydrochloride.The patients in the experimental group were treated with memantine hydrochloride.The adverse reactions of the two groups were compared.Results The incidence of adverse reactions in the experimental group was 6.67%,the rate of adverse reaction in the reference group was 26.67%,and the difference between the two groups was statistically significant(P<0.05).Before treatment,there was no significant difference in MoCA and MMSE scores between the two groups(P>0.05).After treatment,the scores of MoCA and MMSE in the experimental group were higher than those in the reference group,and the difference was statistically significant(P<0.05).Conclusion The effect of memantine hydrochloride in patients with Parkinson's disease is remarkable,and it can improve the survival of patients.
作者
解志坚
滕晶
刘伟
杨金丹
潘雪
XIE Zhijian;TENG Jing;LIU Wei;YANG Jindan;PAN Xue(Internal-traditional Chinese Medicine Department,Harbin Traditional Chinese Medicine Hospital,Harbin Heilongjiang 150076,China)
出处
《中国继续医学教育》
2018年第24期123-124,共2页
China Continuing Medical Education
