摘要
目的:探讨血管内皮生长因子(Vascular endothelial growth factor,VEGF)和基质金属蛋白酶-7(Matrix metalloproteinase-7,MMP-7)在胆管癌组织中的表达及其预后的关系。方法:选取本院2010年5月至2012年8月手术切除胆管癌组织标本35例为观察组,非胆管癌组织标本(癌旁胆管组织)30例为对照组。利用免疫组织化学SP法检测在胆管癌组织及非胆管癌组织中VEGF和MMP-7的表达情况,分析其患者性别、年龄、病理分化、肿瘤大小、淋巴转移等临床特征之间的关系及其与预后的相关性。结果:(1)观察组VEGF和MMP-7的阳性表达率分别为68.57%、71.43%,对照组VEGF和MMP-7的阳性表达率分别为23.33%、36.67%,观察组中VEGF和MMP-7的阳性表达率均明显高于对照组(P<0.05);(2)观察组VEGF以及MMP-7的阳性表达均与患者性别、年龄、肿瘤大小无关,而与分化程度及肿瘤的淋巴结转移有关(P<0.05);(3)胆管癌患者术后5年总体生存率为22.86%(8/35),VEGF和MMP-7表达均与生存期<5年相关(P<0.05)。结论:VEGF和MMP-7在胆管癌组织中高表达,与胆管癌的分化程度及淋巴结转移关系密切,对胆管癌预后的评估具有重要的意义。
Objective:To investigate the expression of vascular endothelial growth factor(VEGF)and matrix metalloproteinase-7(MMP-7)in cholangiocarcinoma and their relationship with prognosis.Methods:Thirty five cases of bile duct carcinoma tissues and 30 cases of non-bile duct carcinoma tissues from May 2010 to August 2012 in our hospital were selected as the research objects.The bile duct carcinoma tissues were selected as observation group,and the non-bile duct carcinoma tissues as control group.The expression of VEGF and MMP-7 in cholangiocarcinoma tissues and non-cholangiocarcinoma tissues was detected by immunohistochemical SP method.Results:(1)The positive expression rates of VEGF and MMP-7 in observation group were 68.57%,71.43%,and 23.33%,36.67%in control group;the positive expression of VEGF and MMP-7 in observation group were higher than those of the control group(P<0.05);(2)The positive expression of VEGF and MMP-7 in observation group was not related to the sex,age and tumor size,but was related to the degree of differentiation and lymph node metastasis(P<0.05);(3)The overall survival rate was 22.86%(8/35)in the 5 year after operation,and the expression of VEGF and MMP-7 was correlated with the survival<5 years(P<0.05).Conclusion:VEGF and MMP-7 are highly expressed in cholangiocarcinoma,which is closely related to the degree of differentiation and lymph node metastasis of cholangiocarcinoma,and is of great significance in the evaluation of prognosis of cholangiocarcinoma.
作者
买二辉
李四桥
雷霆
户平安
査中明
张树交
Mai Er-hui;Li Si-qiao;Lei Ting;Hu Ping-an;Cha Zhong-ming;Zhang Shu-jiao(Department of surgical;Luoyang Central Hospital,Henan Luoyang 471009)
出处
《四川生理科学杂志》
2018年第3期188-190,共3页
Sichuan Journal of Physiological Sciences
关键词
血管内皮生长因子
胆管癌
基质金属蛋白酶-7
预后
Vascular endothelial growth factor
Cholangiocarcinoma
Matrix metalloproteinase-7
Prognosis
