摘要
目的:探讨血清铁蛋白(SF)及β_2微球蛋白(β_2M)在糖尿病合并腔隙性脑梗死(LI)发病中的作用及相互关系。方法:将127例经磁共振(MRI)证实的LI患者根据是否合并糖尿病分为糖尿病合并LI组(n=65)和非糖尿病合并LI组(n=62)。另将年龄、性别等相匹配的体检者作为对照组(n=60)。检测并比较各组的SF、β_2M、LI数目及其他相关指标。分析SF、β_2M与LI数目及三者与HbA1c水平的相关性。结果:糖尿病合并LI组SF、β_2M均明显高于非糖尿病合并LI组和对照组(P<0.01);糖尿病合并LI组LI数目高于非糖尿病合并LI组(P<0.01)。SF、β_2M、LI数目与HbA1c水平正相关(P<0.01);SF与LI数目正相关(P<0.01);β_2M和LI的数目无相关性。在糖尿病合并LI患者中,HbA1c是SF水平的独立影响因素;HbA1c和收缩压是β_2M的独立影响因素;SF是LI数目的独立影响因素。结论:糖尿病合并LI患者SF、β_2M、LI数目较非糖尿病合并LI患者高;SF在糖尿病合并LI的发生发展中起重要作用,可能是糖尿病合并LI发生的预测因子。
Objective:To investigate the role and relationship of serum ferritin(SF)andβ2 microglobulin(β2M)in the pathogenesis of diabetic patients complicated with lacunar infarction(LI).Methods:A total of 127 patients with LI confirmed by magnetic resonance were divided into diabetes mellitus combined with LI group and non-diabetic LI group according to whether they had diabetes or not.In addition,physical examinees matched with age and sex were taken as control group.The number of SF,β2M,LI,and other related indicators of each group were detected and compared.Pearson linear correlation analysis and multiple stepwise linear regression analysis were used to analyze the correlation between SF,β2M,and LI,as well as the correlation between the three and HbA1c levels and their influencing factors.Results:The levels of SF andβ2M in the diabetic group were significantly higher than those in the non-diabetic group(P<0.01).The number of LI in the diabetes mellitus combined with LI group was higher than that in the non-diabetic LI group(P<0.01).The number of SF,β2M,and LI was positively correlated with HbA1c level(P<0.01);SF was positively correlated with LI number(P<0.01);there was no correlation betweenβ2M and LI number.Regression analysis suggested that HbA1c was an independent influencing factor of SF levels in patients with diabetes mellitus and LI;HbA1c and systolic blood pressure were independent influencing factors ofβ2M;SF was an independent influencing factor of LI number.Conclusions:The numbers of SF,β2M,and LI in patients with diabetes mellitus complicated with LI is higher than that in non-diabetic patients with LI.SF plays an important role in the development of diabetes mellitus combined with LI,which may be a predictor of diabetes mellitus combined with LI.
作者
李晓艳
张乐
李彬
姜丹
尹世杰
LI Xiao-yan;ZHANG Le;LI Bin;JIANG Dan;YIN Shi-jie(Department of Neurology,Anhui Second People’s Hospital,Hefei 230041,Anhui,China;Department of Neurology,the Frist Affiliated Hospital of Anhui Medical University,Hefei 230000,Anhui,China)
出处
《中国临床医学》
2018年第5期716-719,共4页
Chinese Journal of Clinical Medicine
