摘要
目的探讨高频超声对无症状高尿酸血症患者关节病变的早期筛查价值。方法选取164例无症状高尿酸血症患者及100例健康对照者。对双侧第一跖趾关节、踝关节及膝关节进行高频超声检查,分析两组病变关节阳性率、病变关节分布情况及超声表现结果。对患者进行2年随访,观察患者出现急性痛风性关节炎的阳性率。结果经过高频关节超声检查,无症状高尿酸血症患者中发现病变关节阳性率高于对照组(P<0.05)。无症状高尿酸血症组第一跖趾关节病变66个,踝关节病变17个,膝关节病变10个。随访2年,各组的急性痛风性关节炎的发生率比较有差异(P<0.05)。结论可以利用高频超声对无症状高尿酸血症患者早期关节病变情况进行筛查,为患者开始降尿酸的时机提供更多依据,减少高尿酸血症带来的关节损害。
Objective To investigate the early application of high-frequency ultrasound in the screening for arthropathy in the patients with asymptomatic hyperuricemia.Methods Totally 164 patients with asymptomatic hyperuricemia and 100 healthy controls were selected.The bilateral first metatarsophalangeal joint,ankle joint and knee joint were examined by high-frequency ultrasonography.The positive rate and distribution of joint lesions and ultrasonographic manifestations were observed.The patients in the three groups were followed up for two years to observe the incidence of acute gouty arthritis.Results Totally 93 joints(9.451%)were found to have lesions under high-frequency ultrasound in the patients with asymptomatic hyperuricemia,including 66 lesions in the first metatarsophalangeal joint,17 lesions in the ankle joint,and 10 lesions in the knee joint.The incidence of arthropathy in the patients was higher than that in the healthy controls,with statistically significant difference(P<0.05).During the follow-up of two years,the incidence of acute gouty arthritis had statistical difference between the groups(P<0.05).Conclusions These findings may support high-frequency ultrasound is useful to find earlystage arthropathy in patients with asymptomatic hyperuricemia,and is to help for early intervention treatment of the patients and to avoid joint damage due to hyperuricemia.
作者
刘慧聪
宋星慧
唐开奖
覃玉花
蒋茵
Hui-cong Liu;Xing-hui Song;Kai-jiang Tang;Yu-hua Qin;Yin Jiang(Department of Rheumatology and Immunology,Liuzhou Worker’s Hospital,Liuzhou,Guangxi 545005,China)
出处
《中国现代医学杂志》
CAS
2018年第32期73-76,共4页
China Journal of Modern Medicine
基金
广西壮族自治区卫生和计划生育委员会科研自筹经费课题(No:Z2015147)
关键词
痛风性关节炎
无症状高尿酸血症
高频超声
gouty arthritis
asymptomatic hyperuricemia
high-frequency ultrasound
