摘要
微小RNA(miRNA)是一类由内源性基因编码的非编码单链RNA分子,参与基因转录后调控。在口腔鳞状细胞癌研究中,miRNA的异常表达可通过靶基因或信号通路影响肿瘤的生长,肿瘤细胞的凋亡、侵袭、转移、放射治疗与化学治疗敏感性等多个方面,其可能作为早期诊断和预后的标志物,具有良好的临床应用潜力。本文对miRNA在口腔鳞状细胞癌的异常表达,以及miRNA-靶基因/下游信号通路-肿瘤效应进行综述,并展望miRNA在临床应用中的前景。
MicroRNAs(miRNAs)are a series of noncoding single-stranded RNA molecules encoded by endogenous genes that affect post-transcriptional gene regulation.Aberrant expression of miRNA involved in oral squamous cell carcinomas is related to tumour growth,cellular apoptosis,invasion,metastasis,radiosensitivity and chemosensitivity.Such aberrant expression regulates target genes or signalling pathways and can potentially be applied to clinic as a kind of biomarker in early diagnosis and prognosis.Accordingly,this review generalizes the association between ectopic miRNA and oral squamous cell carcinoma.Simultaneously,it summarizes the axis,namely,miRNA-target gene/downstreamsignaling pathway-tumorous effect,and forecasts the prospect of clinical application.
作者
方川
李雅冬
Fang Chuan;Li Yadong(Dept.of Oral and Maxillofacial Surgery,The First Affiliated Hospital,Chongqing Medical University,Chongqing 630014,China)
出处
《国际口腔医学杂志》
CAS
CSCD
2018年第6期646-651,共6页
International Journal of Stomatology
基金
重庆市卫生与计划生育委员会医学高端后备人才培养项目(2017HBRC004)~~
