摘要
口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)的形成是多种因素作用导致基因突变的结果。淋巴结局部转移是OSCC的最主要也是对治疗预后影响最大的生物学行为之一。OSCC发生发展的原因及其淋巴转移的生物学机制尚未明确。探求OSCC发生和转移过程中的生物学机制对明确OSCC的发病机制和寻找潜在的治疗靶点有重要意义。本文从不同角度对OSCC发病及转移机制进行综述。
The formation of oral squamous cell carcinoma is the accumulation of multiple gene mutations.Lymph node metastasis is one of the most important biological behaviors of OSCC,and it also has the greatest influence on the prognosis.The molecular biological mechanism of OSCC is still unclear.Exploring the molecular biological mechanism of OSCC is of great significance to clarify the pathogenesis of OSCC and to find potential therapeutic targets.This article reviews the pathogenesis of OSCC from the molecular biology perspective.
作者
王倩
侯大为
WANG Qian;HOU Da-wei(Department of Oral and Maxillofacial Surgery,People's Hospital of Gansu Province.Lanzhou 730000,China)
出处
《口腔医学研究》
CAS
北大核心
2018年第11期1164-1167,共4页
Journal of Oral Science Research
关键词
口腔鳞状细胞癌
发病机制
增殖
转移
Oral squamous cell carcinoma
Pathogenesis
Proliferation
Metastasis
