摘要
目的探讨醋酸甲地孕酮(MA)改善中晚期结直肠癌患者化疗后骨髓抑制和改善患者生活质量的应用价值。方法将98例中晚期结直肠癌患者随机分为实验组和对照组,每组各49例。实验组应用化疗加口服MA分散片;对照组仅进行化疗。两组均进行2周期XELOX标准方案化疗,观察并分析两组骨髓抑制、KPS评分、体重及生活质量的变化情况。结果两组骨髓抑制、KPS评分及体重比较,差异有统计学意义(P <0.05),实验组较对照组生活质量改善(P <0.05)。结论 MA能有效改善中晚期结直肠癌患者化疗后骨髓抑制,提高生活质量、且不增加毒副作用,值得进一步推广。
Objective To evaluate the clinical application of Megestrol Acetate(MA)in improving chemotherapy-induced myelosuppression and quality of life in advanced colorectal cancer patients.Methods Ninetyeight cases of colorectal cancer were involved and randomly divided into two groups.All patients received standard chemotherapy(XELOX).A total of 49 patients in observation group received additional MA.Myelosuppression and quality of life were evaluated after 2 cycles of standard chemotherapy.Results MA exerted a significant improvement in chemotherapy-induced myelosuppression,KPS score,body weight,and quality of life(P<0.05).Conclusion MA can effectively improve bone marrow suppression and quality of life in patients with advanced colorectal cancer after chemotherapy.
作者
赵静
底彦
韩华
高海娜
支政
Jing Zhao;Yan Di;Hua Han;Hai-na Gao;Zheng Zhi(Department of Oncology,Hebei General Hospital,Shijiazhuang,Hebei 050017,China;Department of Gynecology,Hebei General Hospital,Shijiazhuang,Hebei 050017,China;Department of Endocrinology,the Second Hospital of Shijiazhuang,Shijiazhuang, Hebei 050051,China;Department of Basic Medicine,Hebei University of Chinese Medicine, Shijiazhuang,Hebei 050200,China)
出处
《中国现代医学杂志》
CAS
2018年第33期46-50,共5页
China Journal of Modern Medicine
基金
河北省2013年医学科学研究计划项目(No:20130116)
关键词
结直肠肿瘤
醋酸甲地孕酮
骨髓抑制
KPS
生活质量
Megestrol Acetate
advanced colorectal cancer
myelosuppression
KPS
quality of life
